Changes in a composite variability index (CVI) and bispectral index (BIS) in response to standardized pain stimuli during propofol remifentanil infusion.
Completed
- Conditions
- diepte van anesthesie tijdens operatieoptimize anesthesia
- Registration Number
- NL-OMON33289
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
All patients: Age > 18 years and < 55 years
Study group: ASA class I and II patients requiring general anesthesia for elective surgical procedures
Exclusion Criteria
patient refusal
weight less than 70% or more than 130% of ideal body weight,
neurological disorder
recent use of psycho-active medication, including alcohol.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Changes of the BIS and CVI after a standard pain stimulus during various<br /><br>steady-state effect-site BIS levels and remifentanil as calculated by the<br /><br>software program Rugloop II (Demed Engineering, Temse, Belgium). Continuous<br /><br>bilateral BIS values throughout the study period.</p><br>
- Secondary Outcome Measures
Name Time Method <p>to compare the changes in other vital signs such as heart rate and blood<br /><br>pressure compared to CVI in response to a standardized noxious stimulus during<br /><br>various targeted pseudo-steady-state concentrations of remifentanil and various<br /><br>steady state level of BIS as guided by propofol effect compartment controlled<br /><br>TCI (closed-loop). </p><br>