Comprehensive Interpretation of the Importance of Skeletal Muscle Mass on Prognosis and Recovery in Cardiac Arrest Survivors: From Machine Learning to Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- skeletal muscle mass
研究概览
简要总结
The objective of this research project is to develop an automated muscle mass measurement system based on computed tomography (CT) images using deep learning and artificial intelligence, and to construct a prognostic prediction model for patients who have experienced cardiac arrest and undergone resuscitation. The model will be validated using multicenter registry data and medical imaging. Furthermore, a clinical trial involving core muscle rehabilitation for post-resuscitation patients will be conducted to evaluate both short-term and long-term outcomes, aiming to comprehensively understand the impact of muscle mass on the prognosis of patients after cardiac arrest.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-traumatic adult patients who experienced sudden cardiac arrest
- •Achieved sustained return of spontaneous circulation (ROSC) for more than five minutes following successful resuscitation
- •Admitted to the ICU
- •Survived beyond 72 hours without successful weaning from mechanical ventilation
排除标准
- •Age under 18 years
- •Pregnancy
- •Expected to be weaned from mechanical ventilation within 48 hours
- •Terminal-stage cancer or unwillingness to receive aggressive treatment
- •Unavailability of ICU care due to overcrowding in the emergency intensive care unit
- •Refusal to participate in the study by the patient or family members
- •Presence of an implanted pacemaker or defibrillator
- •Open wounds, severe edema, or deep vein thrombosis in the lower limbs
- •Pre-arrest status limited to wheelchair use or bedridden, unable to ambulate
研究组 & 干预措施
control group
Intervention Group
Participants in the arm group only performed joint-assisted movement.
干预措施: Enhanced Rehabilitation Program (Behavioral)
结局指标
主要结局
skeletal muscle mass
时间窗: 21 days
Muscle changes were measured weekly using a handheld ultrasound.
次要结局
未报告次要终点