Assessment of Seminal Levels of Cystatin C and Endoglin in Infertile Men With Varicocele

Not Applicable

Completed

• Conditions: Infertility, Male; Varicocele
• Interventions: Procedure: Varicocelectomy

• Registration Number: NCT04856579
• Lead Sponsor: Benha University

Brief Summary

Varicocele is a major contributor in male infertility. The improvement of sperm parameters after varicocelectomy supports this contribution. The pathophysiological mechanisms of varicocele-induced male infertility are still under investigation. Cystatin C (Cys C) and endoglin are secreted glycoproteins that recently linked to several cellular changes common in varicocele like apoptosis and autophagy.

Detailed Description

Subinguinal varicocelectomy under general anesthesia and complete aseptic condition was done to infertile men with varicocele

Study Timeline

• Study Start: 2019-01-01
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-04
• Study First Submitted: 2021-04-06
• Study First Submitted QC: 2021-04-20
• Last Update Submitted: 2021-04-20
• Study First Posted: 2021-04-23
• Last Update Posted: 2021-04-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Infertile men
• Varicocele
• Poor sperm parameters

Exclusion Criteria

• Men with systemic diseases
• Infertile men due to other causes than varicocele

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Varicocelectomy	Varicocelectomy	Subinguinal varicocelectomy under general anesthesia and complete aseptic condition

Primary Outcome Measures

Name	Time	Method
The Quality of Semen	6 months	According to WHO 2010 guidelines regarding semen analysis; * Sperm concentration (to be more than 15 million sperm per milliliter).; * Sperm motility (not less than 60% progressive motility).; * Sperm morphology (not less than 6% normal morphology).

Trial Locations

Locations (2)

Benha Faculty of Medicine; 🇪🇬 Banhā, Egypt

Benha Faculty of Medecine; 🇪🇬 Banhā, Egypt