Comparison between hyperbaric Ropivacaine and hyperbaric Bupivacaine in patients undergoing inguinal and perineal surgeries under spinal anaesthesia.
- Conditions
- Medical and Surgical,
- Registration Number
- CTRI/2023/02/050035
- Lead Sponsor
- Dr D Y Patil Medical college Hospital and Research Centre Pune
- Brief Summary
Spinal anesthesia for most lower abdominal and lower limb surgeries are carried out using injection bupivacaine heavy, which produces effective autonomic, sensory and motor blockade of the dermatomes above and below the level of intrathecal injection. However, bupivacaine is a long-acting agents with increased risks of re-entrant arrhythmias and cardiac depression which lead to the development of ropivacaine, which has increased threshold in terms of risk of CVS or CNS toxicity unlike bupivacaine. Also, with the advent of day care surgical procedures and early postoperative patient mobilization to aid in better prognostic outcome, using a long-acting agent such as bupivacaine becomes a deterrent. Additionally, the use of hyperbaric ropivacaine for subarachnoid blockade is still in nascent stages in our country. We require more studies to evaluate and assess the degree of effective ascend as well as descend of sensory and motor block with hyperbaric ropivacaine in order to encourage more clinical use of this drug and help us take a step towards better patient mobilization and care postoperatively for routine day care surgeries.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 30
- Patients undergoing inguinal and perineal surgeries under spinal anesthesia.
- Hemodynamically stable patients with all routine investigations within normal limits with no co-morbidities.
- Patients who are not on any cardiac related drugs.
- Availability of informed consent.
- Patients with ASA physical status 3 or more.
- Patients below 18 years and above 60 years of age.
- Patients posted for emergency procedures.
- Patients with major neurological, cardiac, respiratory, metabolic, renal, hepatic disease or any coagulation abnormalities.
- Patients contraindicated for spinal anesthesia.
- Patients with known allergies to the study drugs.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time taken for the onset of sensory block followed by 2 minutes to 15 minutes Time taken to T8 level sensory blockade post subarachnoid block with either injection bupivacaine heavy or injection ropivacaine heavy. 2 minutes to 15 minutes
- Secondary Outcome Measures
Name Time Method Onset and duration of motor blockade 2 minutes to 150 minutes Duration of sensory blockade 150 minutes Intraoperative hemodynamic parameters like heart rate, blood pressure 2 minutes to 150 minutes Time of first micurition At 120 to 150 minutes post subarachnoid block 5.To observe for any incidence of adverse events and for the need of general anesthesia (GA) supplementation. 2 to 20 minutes
Trial Locations
- Locations (1)
DR DY PATIL MEDICAL COLLEGE PUNE
🇮🇳Pune, MAHARASHTRA, India
DR DY PATIL MEDICAL COLLEGE PUNE🇮🇳Pune, MAHARASHTRA, IndiaDr Bhavini ShahPrincipal investigator09850829994drbhavinishah71@gmail.com