NCT02902198RecruitingNot Applicable
Taste Physiology in Obese Volunteers Before and After Bariatric Surgery
University Hospital, Basel, Switzerland1 site in 1 country16 target enrollmentStarted: December 1, 2014Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Effect of tastants on cerebral blood flow measured by functional brain MRI
Study Overview
Brief Summary
The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 55 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
- •right handed
Exclusion Criteria
- •cardiovascular disease
- •neurologic/psychiatric disorders
Outcomes
Primary Outcomes
Effect of tastants on cerebral blood flow measured by functional brain MRI
Time Frame: changes from baseline to one hour after treatment
Secondary Outcomes
- Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations(changes from baseline to one hour after treatment)
- Effect of tastants plasma ghrelin concentrations(changes from baseline to one hour after treatment)
Investigators
Study Sites (1)
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