Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

Not Applicable

Recruiting

• Conditions: Obesity

• Registration Number: NCT02902198
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12
• Study First Submitted: 2016-09-12
• Study First Submitted QC: 2016-09-12
• Study First Posted: 2016-09-15
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-31
• Last Update Posted: 2025-04-03
• Primary Completion: 2026-12
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
• right handed

Exclusion Criteria

• cardiovascular disease
• neurologic/psychiatric disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Effect of tastants on cerebral blood flow measured by functional brain MRI	changes from baseline to one hour after treatment

Secondary Outcome Measures

Name	Time	Method
Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations	changes from baseline to one hour after treatment
Effect of tastants plasma ghrelin concentrations	changes from baseline to one hour after treatment

Trial Locations

Locations (1)

University Hopital Basel; 🇨🇭 Basel, Switzerland