Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

University Hospital, Basel, Switzerland1 site in 1 country16 target enrollmentDecember 2014

ConditionsObesity

Overview

Phase: N/A
Intervention: Not specified
Conditions: Obesity
Sponsor: University Hospital, Basel, Switzerland
Enrollment: 16
Locations: 1
Primary Endpoint: Effect of tastants on cerebral blood flow measured by functional brain MRI
Status: Recruiting
Last Updated: last year

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.

Registry

clinicaltrials.gov

Start Date

December 2014

End Date

December 2027

Last Updated

last year

Study Type

Interventional

Study Design

Crossover

Sex

All

Investigators

Sponsor

University Hospital, Basel, Switzerland

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
•right handed

Exclusion Criteria

•cardiovascular disease
•neurologic/psychiatric disorders

Outcomes

Primary Outcomes

Effect of tastants on cerebral blood flow measured by functional brain MRI

Time Frame: changes from baseline to one hour after treatment

Secondary Outcomes

Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations(changes from baseline to one hour after treatment)
Effect of tastants plasma ghrelin concentrations(changes from baseline to one hour after treatment)