'Post-sarcoidosis' fatigue: a psychoneuroimmunologic approach - 'Post-sarcoidosis' fatigue

Sint Antonius Ziekenhuis0 个研究点目标入组 75 人开始时间: 待定最近更新: 2024年6月18日

适应症

试验速览

暂无简介。

•· Evidence on the presence of active sarcoidosis is absent, over the last 6 months:
•- normal serum parameters (ACE, serum IL-2, calcium)
•- röntgenogram/CTscan: normal or >= 2 yr. stable
•- lungfuction: normal or >= 2 yr. stable (< 10% change of VC or FEV1, < 15%change of DLco)
•· No clinical evidence of disease activity of previously involved organs
•· Sarcoidosis is diagnosed based according to the latest ATS/ERS/WASOG statement on sarcoidosis, i.e.: histologic demonstration of noncaseating granulomas in combination with compatible clinical findings and exclusion of other causes of granuloma formation
•· Capability of giving informed consent

•· Sarcoidosis presented as Löfgren*s syndrome
•· Medication with corticosteroids or other immunosuppressive drugs over the last 6 months
•· Antidepressiva
•· Psychiatric diseases (major depression, schizophrenia, dementia, anorexia nervosa. bulimia nervosa)
•· Sleep apnoea or narcolepsy or restess legs syndrome
•· Any diagnosed disease or any significant abnormal and clinically relevant laboratory test that could possibly contribute to fatigue
•(Hb, BSE, leukocytes and differentiation, Na, K, Ca, creatine, bicarbonate, AF, ALAT, creatine phosphokinase (CPK), glucose, total protein, protein spectrum, thyroid stimulating hormone (TSH), ferritine en urine)
•· Body Mass Index (BMI): >= 45 or BMI<17
•· Abuse of alcohol, drugs or other substance

发起方