Effect of Office-Based Short-duration High-Impact Exercise on Bone Mineral Density in Healthy Premenopausal Wome

Not Applicable

• Conditions: osteoporosis

• Registration Number: JPRN-UMIN000000533
• Lead Sponsor: Tohoku University Graduate School of Medicine

Brief Summary

inety-one healthy premenopausal women were randomized to receive stretching exercise (SE) or HIE (stretching, along with up to 5 x 10 vertical and versatile jumps) for 12 months. The bone mineral density (BMD) of the lumbar spine and proximal femur was measured using dual-energy X-ray absorptiometry. Several cardiovascular risk factors and leg strength also were assessed. An accelerometer-based recorder was used to measure daily impact loading in four 1-week samples. The progression of the HIE program was ensured by the accelerometer. Thirty-three women (71.7%) in the SE group and 34 (75.6%) in the HIE group completed the study. There was a significant difference in the change in the femoral neck BMD between the groups in favor of the HIE group [0.6% (95% CI: 0.4, 1.7) vs. 1.0% (95% CI: 2.2, 0.2)]. Adiponectin, LDL, HDL, and the leg strength of participants in both the groups improved during the intervention. These finding suggested that office-based brief HIE can be recommended for premenopausal women for preventing bone mineral loss.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2006-11-01
• Study Start: 2006-12-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up complete
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

Not provided

Exclusion Criteria

Medication of steroid hormone (corticosteroids, estrogen), Metabolic diseases related to calcium turnover (hyper and hypothyroidism, hyper and hypo-parathyroidism etc) Unable to complete 1 year intervention and examination Pregnant Within 1 year of delivery Within 6 month of breast feeding Ovariectomized Diagnosed as osteoporosis Patients with severe diseases such as cancer

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bone mineral density as assessed by DXA (lumbar spine L1-4, left femoral neck and trochanter), and by QUS(calcaneus)

Secondary Outcome Measures

Name	Time	Method
Bone metabolism marker: cross-linked N. telopetide of type I Collagen(NTX); bone alkaline phosphatase(BAP)