NL-OMON48103
Recruiting
Not Applicable
Cardiorespiratory fitness in newly diagnosed patients with Relapsing Remitting Multiple Sclerosis compared to matched healthy controls: already lagging behind from the start? - VO2max in early MS / LOW2early
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis (MS)
- Sponsor
- Vrije Universiteit Medisch Centrum
- Enrollment
- 32
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •MS patients
- •In order to be eligible to participate in this study, the MS patients must meet all of the following criteria:
- •\- definite diagnosis of Relapsing Remitting MS according to the most recent international diagnostic criteria;
- •\- diagnosis within 12 months prior to inclusion date;
- •\- disease severity: EDSS score of maximal 2 with normal pyramidal and cerebellar functions (i.e. Functional Systems Score for pyramidal functions \= 0 and Functional Systems Score for cerebellar functions \= 0\).
- •\- age at definite diagnosis between 18\-65 years.
- •Healthy Siblings/Controls (controls)
- •In order to be eligible to participate in this study, the healthy controls must meet the following criteria:
- •\- healthy sibling of participant with MS, and matching with respect to sex, age (± 5 years), level of physical activity in the past year;
- •\- healthy persons, matching to MS participants with respect to sex, age (± 5 years), and level of physical activity in the past year.
Exclusion Criteria
- •\- Physician\-confirmed diagnosis of (other) neurological disorders or systemic or malignant neoplastic diseases.
- •\- Serious comorbidities precluding Cardiopulmonary Exercise test (CPET) or Lung function examination.
- •\- Use of heart rate regulating medication (e.g. Beta\-blockers).
- •\- Use of medication for lung diseases.
- •\- Being pregnant, or receiving medical help/fertility treatment to become pregnant.
- •\- Body Mass Index of 30 or higher.
- •\- Sports and exercise activities in the past year of \> 10 hours/week.
- •\- Does not speak Dutch.
Outcomes
Primary Outcomes
Not specified
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