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Clinical Trials/NCT02589353
NCT02589353CompletedPhase 4

The Role of Salivary Contents in Taste Perception of Starch and Its Hydrolysis Products

Oregon State University1 site in 1 country157 target enrollmentStarted: April 21, 2017Last updated:
Conditions
Interventions
Drugs

Trial Snapshot

Phase
Phase 4
Status
Completed
Enrollment
157
Locations
1
Primary Endpoint
Detection of glucose polymers in the presence of acarbose

Study Overview

Brief Summary

Although salivary contents play a major role in the early stage of food digestion process, their role in taste perception of glucose polymers is essentially unknown. It is hypothesized that the differences in salivary contents, more specifically salivary amylase concentration and activity, influence taste perception of glucose polymers and ultimately eating behavior, which is related to risks in various diseases. The current project will investigate the variation in salivary contents across individuals and its role in taste perception of glucose polymers.

Study Design

Study Type
Interventional
Allocation
Na
Intervention Model
Single Group
Primary Purpose
Basic Science
Masking
None

Eligibility Criteria

Ages
18 Years to 60 Years (Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • self-reported healthy adults between the ages of 18-60 who are fluent in English.

Exclusion Criteria

  • adults 61 years old and above
  • pregnant women
  • taking any prescription pain/ insulin medication
  • has a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)
  • has current oral lesions, canker sores, or piercings
  • has a history of food allergy

Arms & Interventions

Acarbose

Experimental

Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain ~484 microgram acarbose; total maximum exposure of each subject to acarbose will be ~14-30 mg each session (1-20 sessions)

Intervention: Acarbose (Drug)

Outcomes

Primary Outcomes

Detection of glucose polymers in the presence of acarbose

Time Frame: up to 5 years

There is only one outcome measure, that is the detection of glucose polymers. Subjects will be asked to discriminate a target sample (glucose polymers). Three samples will be applied using cotton swabs on the subjects' tongue (one at a time): 2 blanks (water + acarbose) and 1 target stimuli (glucose polymer solution + acarbose). Subjects will be asked to identify the target sample. The number of subjects who correctly identify the target stimuli will be counted and will be statistically analyzed to determine whether glucose polymer can be detected without the confounding effect of salivary alpha amylase hydrolysis.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Juyun Lim

Associate Professor

Oregon State University

Study Sites (1)

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