The Role of Salivary Contents in Taste Perception of Starch and Its Hydrolysis Products
Trial Snapshot
- Phase
- Phase 4
- Status
- Completed
- Sponsor
- Oregon State University
- Enrollment
- 157
- Locations
- 1
- Primary Endpoint
- Detection of glucose polymers in the presence of acarbose
Study Overview
Brief Summary
Although salivary contents play a major role in the early stage of food digestion process, their role in taste perception of glucose polymers is essentially unknown. It is hypothesized that the differences in salivary contents, more specifically salivary amylase concentration and activity, influence taste perception of glucose polymers and ultimately eating behavior, which is related to risks in various diseases. The current project will investigate the variation in salivary contents across individuals and its role in taste perception of glucose polymers.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 60 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •self-reported healthy adults between the ages of 18-60 who are fluent in English.
Exclusion Criteria
- •adults 61 years old and above
- •pregnant women
- •taking any prescription pain/ insulin medication
- •has a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)
- •has current oral lesions, canker sores, or piercings
- •has a history of food allergy
Arms & Interventions
Acarbose
Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain ~484 microgram acarbose; total maximum exposure of each subject to acarbose will be ~14-30 mg each session (1-20 sessions)
Intervention: Acarbose (Drug)
Outcomes
Primary Outcomes
Detection of glucose polymers in the presence of acarbose
Time Frame: up to 5 years
There is only one outcome measure, that is the detection of glucose polymers. Subjects will be asked to discriminate a target sample (glucose polymers). Three samples will be applied using cotton swabs on the subjects' tongue (one at a time): 2 blanks (water + acarbose) and 1 target stimuli (glucose polymer solution + acarbose). Subjects will be asked to identify the target sample. The number of subjects who correctly identify the target stimuli will be counted and will be statistically analyzed to determine whether glucose polymer can be detected without the confounding effect of salivary alpha amylase hydrolysis.
Secondary Outcomes
No secondary outcomes reported
Investigators
Juyun Lim
Associate Professor
Oregon State University