The Role of Salivary Contents in Taste Perception of Starch and Its Hydrolysis Products
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 157
- 试验地点
- 1
- 主要终点
- Detection of glucose polymers in the presence of acarbose
研究概览
简要总结
Although salivary contents play a major role in the early stage of food digestion process, their role in taste perception of glucose polymers is essentially unknown. It is hypothesized that the differences in salivary contents, more specifically salivary amylase concentration and activity, influence taste perception of glucose polymers and ultimately eating behavior, which is related to risks in various diseases. The current project will investigate the variation in salivary contents across individuals and its role in taste perception of glucose polymers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •self-reported healthy adults between the ages of 18-60 who are fluent in English.
排除标准
- •adults 61 years old and above
- •pregnant women
- •taking any prescription pain/ insulin medication
- •has a history of taste or smell loss or other oral disorders (e.g., burning mouth syndrome)
- •has current oral lesions, canker sores, or piercings
- •has a history of food allergy
研究组 & 干预措施
Acarbose
Acarbose solution will be swabbed on the tip of the tongue to inhibit salivary alpha amylase activity; each swab will contain ~484 microgram acarbose; total maximum exposure of each subject to acarbose will be ~14-30 mg each session (1-20 sessions)
干预措施: Acarbose (Drug)
结局指标
主要结局
Detection of glucose polymers in the presence of acarbose
时间窗: up to 5 years
There is only one outcome measure, that is the detection of glucose polymers. Subjects will be asked to discriminate a target sample (glucose polymers). Three samples will be applied using cotton swabs on the subjects' tongue (one at a time): 2 blanks (water + acarbose) and 1 target stimuli (glucose polymer solution + acarbose). Subjects will be asked to identify the target sample. The number of subjects who correctly identify the target stimuli will be counted and will be statistically analyzed to determine whether glucose polymer can be detected without the confounding effect of salivary alpha amylase hydrolysis.
次要结局
未报告次要终点
研究者
Juyun Lim
Associate Professor
Oregon State University