Can whole body vibration training improve muscle function and bone density in children and adolescents with cerebral palsy?

Not Applicable

Completed

• Conditions: Cerebral Palsy; Neurological - Other neurological disorders

• Registration Number: ACTRN12611000465954
• Lead Sponsor: Dr Paul Hofman

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-05-05
• Study Completion: 2019-07-10
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Children and adolescents with cerebral palsy (GMFCS II, III and IV) aged between 8 and 20 years. To be included in the study participants must be able to stand on vibration platform and be able to undertake evaluation of the therapy.

Exclusion Criteria

Participants will be excluded if: 1) they have a fracture of any type within 8 weeks of enrollment, pregnancy and acute thrombosis, muscle or tendom inflammation, renal stones, discopathy or arthritis. 2) there is history of clinically significant organic disease or findings on physical examination, which in the opinion of the investigator would prevent the patient from completing the study. 3) There is history of using any of the following medications, regardless of dose, for at least 1 month, within 3 months of enrollment: anabolic agents, glucocorticoids (does not include inhaled glucocorticoids) or growth hormone. 4) serum 25-hydroxyvitamin D < 50mmol/L 5) received Botulinium toxin injection into lower limbs within 3 months of enrollment. Participants will not receive Botolinium toxin injection throughout duration of the study.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak Jump Force assessed by the Single Two-Legged Jump on the Leonardo ground reaction force plates.[Baseline and 20 weeks after randomisation];Bone mineral density of the non-dominant Tibia assessed by Peripheral Quantitative Computer tomography (pQCT scan)[Baseline and 20 weeks after randomisation]

Secondary Outcome Measures

Name	Time	Method
Body composition assessed by Dual Energy X-Ray Absorptiometry (DEXA scan)[Baseline and 20 weeks after randomisation];Muscle strenght assessed by Chair raise test and 6 minute walk test[Baseline and 20 weeks after randomisation];Quality of life assessed by CP QOL questionnaire.[Baseline and 20 weeks after randomisation];Gait analysis assessed by 3D camera model.[Baseline and 20 weeks after randomisation]