Adjuvant potential of metformin with standard AEDs in persons with active epilepsy: a Randomised controlled trial - NI

Ratnav Singh0 个研究点目标入组 60 人开始时间: 待定最近更新: 2024年4月1日

试验速览

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•1) Clinically diagnosed persons with active epilepsy (PWE) with at least 2 seizures in the past 3 months and on a stable AEDs treatment regimen for last one month.
•2) Either male or female subject of 18 to 60 years old age 3) Pharmacoresistance to at least one tolerated and appropriately chosen and used AED schedules to achieve
•sustained seizure freedom.
•4) Patient ready to give informed consent
•5) Ability to maintain seizure diary

•1) Pregnant or seeking pregnancy and nursing mother
•2) Patient undergoing AED tapering
•3) Patient with active liver disease or persistent liver dysfunction, gallstones or biliary disease
•4) Patient with severe renal impairment (eGFR <45ml/min/1.73m 2) or undergoing dialysis
•5) Patient with known cardiac diseases including heart failure, severe pulmonary disease, chronic alcoholism, sepsis, severe vitamin B12 deficiency.
•6) Patienton any other drugs known to alter seizure threshold or cause interactions with AEDs (e.g. isoniazid,
•theophylline, metronidazole, fluoxetine, fluvoxamine, clarithromycin, erythromycin, fluconazole, etc.) or
•with metformin (e.g. cimetidine, nifedipine, furosemide etc.)
•7) Patient already on metformin therapy for the past 3 months or with a known hypersensitivity to
•8) Poor compliance with AEDs

发起方

Ratnav Singh