Exercise and Vascular Function in Chronic Kidney Disease
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Chronic Renal Insufficiency
- Sponsor
- University of Delaware
- Enrollment
- 76
- Locations
- 1
- Primary Endpoint
- Endothelial Function
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The purpose of this study is to investigate the effects of 12 weeks of aerobic exercise training on blood vessel function in Stages 1-4 Chronic Kidney Disease.
Detailed Description
The endothelium lines the inside of the blood vessels. A healthy endothelial lining acts as a defense mechanism against vascular injury, mediating vascular tone, vascular structure, and blood-vessel wall relations. Endothelial dysfunction marks the occurrence of cardiovascular injuries and is a critical step in the development of cardiovascular disease. Individuals with Chronic Kidney Disease (CKD) have an increased risk of cardiovascular disease and this may be related to poor blood vessel function. Interventions to improve blood vessel function in CKD are needed. Exercise training has been shown to improve blood vessel function in older subjects and those with heart disease but this has not been investigated in CKD. The National Kidney Foundation recommends exercise for dialysis patients to reduce cardiovascular risk however there is very little data regarding the benefits of exercise in earlier stages of CKD. The purpose of this study is to determine the effect of 12 weeks of exercise training on blood vessel function in moderate to severe CKD.
Investigators
David Edwards
Associate Proffessor
University of Delaware
Eligibility Criteria
Inclusion Criteria
- •CKD Exercise and CKD Control Arms: Stage 1 - 4 Chronic Kidney Disease (eGFR 15 - 90 ml/min/1.73m2)
- •Healthy Control Arm: eGFR \> 90 ml/min/1.73m2)
Exclusion Criteria
- •History of cardiovascular disease
- •Uncontrolled hypertension
- •Lung disease
- •Liver disease
- •Immunosuppressant or antiretroviral therapy
- •Current tobacco use
- •Pregnancy
- •Hormone replacement therapy
- •Unable to give consent
Outcomes
Primary Outcomes
Endothelial Function
Time Frame: Change from baseline at 12 weeks
Conduit artery endothelial function assessed by brachial artery flow mediated dilation; Microvascular endothelial function assessed by cutaneous vasodilation in response to local heating measured by microdialysis and laser Doppler flowmetry.
Secondary Outcomes
- Arterial Stiffness(Change from baseline at 12 weeks)
- Microvascular function(Change from baseline at 12 weeks)
- Pulse Wave Analysis(Change from baseline at 12 weeks)
- Oxidative stress contribution to vascular dysfunction(Change from baseline at 12 weeks)
- Endothelial cell oxidative stress(Changes from baseline at 12 weeks)
- Plasma Oxidized Low Density Lipoprotein(Change from baseline at 12 weeks)
- F2-isoprostanes(Change from baseline at 12 weeks)
- Ambulatory Blood Pressure(Change from baseline at 12 weeks)
- Peak Aerobic Capacity(Change from baseline at 12 weeks)
- Physical Function(Change from baseline at 12 weeks)
- Knee Extensor Strength(Change from baseline at 12 weeks)
- Habitual Physical Activity(Change from baseline at 12 weeks)