EXecution of Trans-Esophagus Echo Cardiogram in CardioPulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest

Not Applicable

Completed

• Conditions: Out-Of-Hospital Cardiac Arrest
• Interventions: Device: transesophageal echocardiography examination during cardiopulmonary resuscitation

• Registration Number: NCT05907460
• Lead Sponsor: Far Eastern Memorial Hospital

Brief Summary

The purpose of this single center, randomized clinical control trial is to determine that changing chest compression site during cardiopulmonary resuscitation according to the examination of the TEE could increase the level of end-tidal CO2, which represents the quality of cardiopulmonary resuscitation, or not in adult patients with non-traumatic out-of-hospital cardiac arrest while comparing to those who don't receive examination of transesophageal echocardiography during cardiopulmonary resuscitation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-06-08
• Study First Submitted QC: 2023-06-08
• Study First Posted: 2023-06-18
• Study Start: 2023-06-29
• Primary Completion: 2023-11-19
• Study Completion: 2023-11-19
• Status Verified: 2024-02
• Last Update Submitted: 2024-09-30
• Last Update Posted: 2024-10-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 132

Inclusion Criteria

1. Age ≥ 20 years-old
2. Out-of-hospital cardiac arrest
3. Non-trauma

Exclusion Criteria

1. Obvious signs of death appears, such as separation of head and body, rigor mortis, livor mortis, cankered corpse......etc.
2. Family members clearly express the willing of do not attempt resuscitation or patients who have registered advance care planning not to attempt resuscitation.
3. Patients not suitable for transesophageal ultrasound, such as patients with esophageal tumor, those whose probe cannot be placed......etc.
4. Received Extracorporeal CPR.
5. Achieving sustained ROSC before ED arrival

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention group	transesophageal echocardiography examination during cardiopulmonary resuscitation	Perform examination of transesophageal echocardiography during cardiopulmonary resuscitation and adjust the chest compression site to avoid left ventricular outflow tract according to the result of transesophageal echocardiography

Primary Outcome Measures

Name	Time	Method
Rate of sustained return of spontaneous circulation (ROSC)	20 minutes after ROSC	successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR) for at least 20 minutes

Secondary Outcome Measures

Name	Time	Method
Rate of any return of spontaneous circulation	1 minutes after ROSC	successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR)
Rate of survival to ICU admission	48 hours after ROSC	Successful restoration and stabilization of a patient's heartbeat and circulation, enabling safe transfer to the ICU.
Rate of survival to discharge	6 months after ROSC	successful restoration and maintenance of a patient's heartbeat and blood circulation and able to complete treatment course till discharge
Rate of discharge with favorable neurological outcomes	6 months after ROSC	using cerebral performance category score to measure neurologic outcomes of the patient at the time while patient's discharge. CPC1 and 2 are consider as favorable neurological outcomes, CPC3 and 4 are consider as unfavorable neurological outcomes
end-tidal carbon dioxide (EtCO2)	During resuscitation	measuring end-tidal carbon dioxide during resuscitation

Trial Locations

Locations (1)

Far Eastern Memorial Hospital; 🇨🇳 Banqiao, New Taipei City, Taiwan