Chronic Effects of Two Aerobic-training Models Performed in Water and on Dry Land in Patients With Type 2 Diabetes Mellitus (T2DM).
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 35
- 试验地点
- 1
- 主要终点
- Glycated hemoglobin
研究概览
简要总结
The aim of this study was to analyse the acute and chronic effects of two aerobic-training models performed in water and on dry land on cardiorespiratory, functional, metabolic, hormonal and quality-of-life parameters in patients with type 2 diabetes mellitus (T2DM).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The clinical diagnosis of type 2 diabetes mellitus. Not be performing regular and systematic physical exercise for at least three months.
排除标准
- •Uncontrolled hypertension. Autonomic neuropathy. Severe peripheral neuropathy. Proliferative diabetic retinopathy. Severe nonproliferative diabetic retinopathy. Uncompensated heart failure. Peripheral amputations. Chronic renal failure (GFR by MDRD <30). Muscle or joint injury that prevents physical exercises.
研究组 & 干预措施
Aquatic exercise
The aquatic aerobic training had a duration of 12 weeks and adopted the interval-training method, with intensities ranging between 85 and 100% of second ventilatory threshold (VT2) and total duration of 45 minute per session.
The sessions consisted of warm up, main part and calm down. The warm-up consisted of a walk in deep water at low intensity for three minutes. The main part was intended to aerobic training in deep water, in which subjects walked and / or ran, depending on your fitness level found in pre-training test. The calm down consisted of walking in deep water at low intensity for two minutes and stretching standardized, emphasizing the muscles worked in the main part of the session, with a total duration of approximately five minutes.
干预措施: Aquatic exercise (Other)
Land exercise
The land aerobic training had a duration of 12 weeks and adopted the interval-training method, with intensities ranging between 85 and 100% of second ventilatory threshold (VT2) and total duration of 45 minute per session.
The sessions consisted of warm up, main part and calm down. The warm-up consisted of a walk in athletic track at low intensity for three minutes. The main part was intended to aerobic training in athletic track, in which subjects walked and / or ran, depending on your fitness level found in pre-training test. The calm down consisted of walking in athletic track at low intensity for two minutes and stretching standardized, emphasizing the muscles worked in the main part of the session, with a total duration of approximately five minutes.
干预措施: Land Exercise (Other)
结局指标
主要结局
Glycated hemoglobin
时间窗: Baseline and after 12 weeks of intervention
次要结局
- Fasting plasma glucose.(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Oxidation of tryptophan(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Plasma renin activity.(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Triglycerides.(Baseline and after 12 weeks of intervention.)
- Angiotensin II.(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Postprandial glucose(Baseline and after 12 weeks of intervention.)
- Fasting insulin.(Baseline and after 12 weeks of intervention.)
- C-reactive protein ultrasensitive.(Baseline and after 12 weeks of intervention.)
- 8-isoprostane(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Oxidation of tyrosine residues(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Interleukin 1β(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Leukocyte DNA Methylation(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Insulin resistance (HOMA-IR).(Baseline and after 12 weeks of intervention.)
- Total cholesterol.(Baseline and after 12 weeks of intervention.)
- High density lipoprotein.(Baseline and after 12 weeks of intervention.)
- Low density lipoprotein.(Baseline and after 12 weeks of intervention.)
- Purines(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Interleukin 6(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Content of reative species (DCF)(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- superoxide dismutase (SOD)(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Catalase (CAT)(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Water-soluble Fluorescent Substances(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Glutathione peroxidase (GPX)(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Total radical-trapping antioxidant potential (TRAP)(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Interleukin 10(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
- Global Histone Deacetylases activity(Before and after a session of 45 minutes of exercise; baseline and after 12 weeks of intervention.)
研究者
Rodrigo Sudatti Delevatti
Effects of two models of aerobic training performed in different environments in patients with type 2 diabetes mellitus
Hospital de Clinicas de Porto Alegre