Cognitive-motor Telerehabilitation in Multiple Sclerosis
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- Universitair Ziekenhuis Brussel
- Enrollment
- 90
- Locations
- 2
- Primary Endpoint
- Change in Digit span backwards
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The primary goal of this project is providing evidence that a home-based combined cognitive-motor training program improves cognition in persons with multiple sclerosis (MS), compared to single cognitive and motor rehabilitation. Secondary goals are to assess the effects on walking performance and to identify the mechanisms of improvement and predictors of treatment response. The main backbone of this project will be a randomized controlled two-centre clinical trial, in which an at-home computerised cognitive-motor rehabilitation program using telemedicine aimed at improving working memory in persons with MS will be evaluated. Based on the information gathered during this trial, possible mechanisms of improvement will be identified by analysing anatomical and neurophysiological changes on structural MRI and resting-state and task-related EEG before and after rehabilitation. Furthermore, factors that can predict treatment response to the rehabilitation program will be identified.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinically definite multiple sclerosis (revised McDonald criteria 2017)
- •Expanded Disability Status Scale (EDSS) below 6.0
- •Digit span backwards z-score between \[-3 and -0.5\] standard deviations below the median of the normative values
- •Age between 18 and 65
- •Able to safely perform motor rehabilitation in the home situation (assessed by rehabilitation physician and/or occupational or physiotherapist)
Exclusion Criteria
- •Cognitive rehabilitation within six months before inclusion
- •Inpatient multidisciplinary rehabilitation program within three months before inclusion or planned inpatient program during trial
- •Start of or switch in immunomodulator treatment within three months before inclusion
- •Less than one month post-exacerbation
- •Major psychiatric or medical disorder that could influence cognitive functions
- •Combined vision with optimal correction below 0.6 on Snellen Visual Acuity Test
- •Unable or unwilling to undergo EEG or MRI
- •Refusing informed consent
Outcomes
Primary Outcomes
Change in Digit span backwards
Time Frame: 0 weeks, 12 weeks, 24 weeks, 64 weeks
Measure of working memory
Secondary Outcomes
- Change in Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS)(0 weeks, 12 weeks, 24 weeks, 64 weeks)
- Change in Corsi backwards(0 weeks, 12 weeks, 24 weeks, 64 weeks)
- Change in Expanded Disability Status Scale (EDSS)(0 weeks, 12 weeks, 24 weeks, 64 weeks)
- Change in 6-Minute Walk Test (6MWT)(0 weeks, 12 weeks, 24 weeks, 64 weeks)
- Change in 25-Foot Walk Test (25FWT)(0 weeks, 12 weeks, 24 weeks, 64 weeks)
- MRI T1 3D BRAVO scan(0 weeks, 12 weeks, 24 weeks)
- Change in 9-Hole Peg Test (9HPT)(0 weeks, 12 weeks, 24 weeks, 64 weeks)
- MRI T2 FLAIR 3D Cube scan(0 weeks, 12 weeks, 24 weeks)
- Diffusion weighted image (DWI)(0 weeks, 12 weeks, 24 weeks)
- Synthetic MRI(0 weeks, 12 weeks, 24 weeks)
- resting-state EEG(0 weeks, 12 weeks)
- task-related EEG - auditory oddball paradigm(0 weeks, 12 weeks)
- task-related EEG - adjusted SDMT paradigm(0 weeks, 12 weeks)
- task-related EEG - n-back paradigm(0 weeks, 12 weeks)