Automated Telephone System to Improve Treatment Adherence in People With Depression

Not Applicable

Completed

• Conditions: Depression

• Registration Number: NCT00136240
• Lead Sponsor: Boston Medical Center

Brief Summary

This study will determine the efficacy of a computerized telephone system called Telephone-Linked Care (TLC) in improving adherence to antidepressant medication regimens in people with depression.

Detailed Description

The purpose of this study is to test the efficacy of a computerized telephone system called TLC (Telephone-Linked Care) in helping subjects adhere to their antidepressant medication regimens.

Study Timeline

• Study Start: 2003-04
• Study First Submitted: 2005-08-25
• Study First Submitted QC: 2005-08-25
• Study First Posted: 2005-08-29
• Primary Completion: 2006-01
• Study Completion: 2006-01
• Status Verified: 2008-08
• Last Update Submitted: 2013-07-24
• Last Update Posted: 2013-07-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 144

Inclusion Criteria

• A clinical diagnosis of major depressive disorder, dysthymic disorder, depressive disorder not otherwise specified, or any combination of the three
• Prescribed at least one antidepressant medication
• Access to a telephone with touch-tone service
• Speak and understand conversational English

Exclusion Criteria

• Current significant alcohol or drug abuse
• Clinical diagnosis of bipolar disorder, schizoaffective disorder, or significant personality disorder
• Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis (ALS), or other neurodegenerative diseases
• Alzheimer's disease and other dementia
• Cancer, undergoing radiation therapy or chemotherapy
• Suffering from Renal disease or on dialysis
• Immunologic disorder (rheumatoid arthritis, systemic lupus erythematosus [SLE], etc.)
• HIV
• Terminal illness
• Homeless
• Legally blind
• Planning to leave the geographic area during the study period

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Antidepressant medication adherence	Measured monthly for 4 months
Adherence to scheduled psychiatry clinic visits	Measured monthly for 4 months

Secondary Outcome Measures

Name	Time	Method
Depression status, measured by self-administered depression inventory scale	Measured at baseline and at 4 month follow-up
General health status, measured by self-rating health survey	Measured at baseline and at 4 month follow-up

Trial Locations

Locations (1)

Boston Medical Center; 🇺🇸 Boston, Massachusetts, United States