Procalcitonin Test for Differentiation of the Cause of Pneumonia

Completed

• Conditions: Pneumonia; Procalcitonin; Cancer
• Interventions: Diagnostic Test: procalcitonin test

• Registration Number: NCT03350802
• Lead Sponsor: National Cancer Center, Korea

Brief Summary

The purpose of this study is to evaluate the usefulness of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

Detailed Description

Serum procalcitonin test is currently used as the biomarker for bacterial infection. Especially, procalcitonin test has been reported to be helpful in differentiating bacterial pneumonia from viral pneumonia, acute exacerbations of interstitial pneumonitis or chronic obstructive lung disease. However, it is not known whether procalcitonin test can help distinguish bacterial pneumonia from non-bacterial pneumonia such as radiation pneumonitis or chemotherapy-induced pneumonitis in patients with cancer.

The aim of this prospective cohort study is to observe the clinical benefits of procalcitonin test for differentiation of the cause of pneumonia in patients with cancer.

Study Timeline

• Study Start: 2014-01-01
• Study First Submitted: 2017-11-17
• Study First Submitted QC: 2017-11-20
• Study First Posted: 2017-11-22
• Primary Completion: 2020-06-30
• Study Completion: 2020-06-30
• Status Verified: 2020-09
• Last Update Submitted: 2020-09-24
• Last Update Posted: 2020-09-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 649

Inclusion Criteria

• Age greater than 18 years
• Patients who have symptoms and suspected imaging findings compatible with pneumonia

Exclusion Criteria

• Patients who have been treated with antibiotics or steroid therapy.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
procalcitonin pneumonia cohort	procalcitonin test	Patients who are suspected of acute pneumonia due to symptoms and imaging findings compatible with pneumonia can be enrolled in this cohort.

Primary Outcome Measures

Name	Time	Method
Procalcitonin level according to the cause of pneumonia in patients with cancer	procalcitonin level is checked within 24hours after visiting hospital	bacterial pneumonia vs. radiation pneumonitis vs chemotherapy-induced pneumonitis

Secondary Outcome Measures

Name	Time	Method
Influence of neutropenia on procalcitonin level in patients with baterial pneumonia	procalcitonin level is checked within 24hours after visiting hospital	bacterial pneumonia with neutropenia vs. without neutropenia
procalcitonin level in patients with atypical pneumonia	procalcitonin level is checked within 24hours after visiting hospital	viral pneumonia vs tuberculosis vs fungal infection

Trial Locations

Locations (1)

Respiratory Clinic, National Cancer Center; 🇰🇷 Goyang-si, Gyeonggi-do, Korea, Republic of