Combined aspirin, clopidogrel and dipyridamole versus aspirin alone in stroke secondary prevention: a safety, tolerability and feasibility study

Completed

• Conditions: Stroke; Ischaemic stroke; Circulatory System

• Registration Number: ISRCTN83673558
• Lead Sponsor: niversity of Nottingham (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-10-28
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

1. Aged 18 years or older
2. Ischaemic stroke on computed tomography (CT)/magnetic resonance imaging (MRI) within 5 years
3. Previous transient ischemic attack (TIA) within 5 years
4. Written informed consent from patient
5. In sinus ryhthm or atrial fibrillation but not suitable for anticoagulation

Exclusion Criteria

1. Thrombocytopenia
2. Severe hypertension
3. Previous cerebral haemorrhage
4. Hypersensitivity or intolerance to aspirin, dipyridamole or clopidogrel
5. Any history of peptic ulcer or gastrointestinal bleeding
6. Severe concomitant medical conditions including acquired immunodeficiency syndrome (AIDS) or cancer
7. Pregnancy or breast feeding
8. Patients needing or already receiving anticoagulant or non-steroidal anti-inflammatory drugs (NSAIDs) other than aspirin therapy

Study & Design

• Study Type: Interventional
• Study Design: Not specified