Comparison of effects of Magnesium sulphate and low dose of Dexmedetomidine on haemodynamic responses to laryngoscopy and intubation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Difference in SBP following laryngoscopy and intubation in the two groups
研究概览
简要总结
this study is purposed to find a suitable drug ( with minimum adverse effects) that can minimise the stress resposes like rise in blood pressure and heart rate during laryngoscopy and intubation in patients planned for surgical intervention under general anaesthesia**.**
laryngoscopy and intubation can be fatal in patients with cardiovascular and cerebral diseases therefore this study will be focused first on ASA grade I and II patients so that it can further be studied on critically ill patients. It can be helpful in decreasing the mortality associated with the simple procedures like laryngoscopy and intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient undergoing elective surgery under general anaesthesia and requiring laryngoscopy and endotracheal intubation Patient belonging to ASA grade I and II Patient with Mallampati grade I and II Patient of either gender Patient of age group 18-60 yrs.
排除标准
- •Patient not willing to participate in the study Patient with the history of difficult intubation Patient with anticipated difficult airway Patient having BMI>30kg/m2 Patient having history of cardiovascular, cerebral, renal, hepatic, bronchial, endocrine disease or psychiatric disorder Patient on anti-hypertensive, hypnotic or narcotic drugs.
结局指标
主要结局
Difference in SBP following laryngoscopy and intubation in the two groups
时间窗: Preoperative (base line values) i.e. before infusion of study drug | During medication at 5min, 10min | Pre-induction of anaesthesia | Just before laryngoscopy and intubation | Post intubation at 1 min, 3min, 5min, 7min and 10min | Then every 5 min till the end of surgery
次要结局
- To compare the heart rate between two groups following laryngoscopy and intubation(To compare Diastolic and Mean blood pressure between two groups)