To compare the effects of Magnesium sulphate and low dose of Dexmedetomidine on haemodynamic responses to laryngoscopy and intubation

Not yet recruiting

Conditions: Measurement and Monitoring,

Registration Number: CTRI/2019/11/022158

Lead Sponsor: UCMS and GTB hospital

Brief Summary: **this study is purposed to find a suitable drug ( with minimum adverse effects) that can minimise the stress resposes like rise in blood pressure and heart rate during laryngoscopy and intubation in patients planned for surgical intervention under general anaesthesia****.**

**laryngoscopy and intubation can be fatal in patients with cardiovascular and cerebral diseases therefore this study will be focused first on ASA grade I and II patients so that it can further be studied on critically ill patients. It can be helpful in decreasing the mortality associated with the simple procedures like laryngoscopy and intubation.**

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 50

Inclusion Criteria

Patient undergoing elective surgery under general anaesthesia and requiring laryngoscopy and endotracheal intubation Patient belonging to ASA grade I and II Patient with Mallampati grade I and II Patient of either gender Patient of age group 18-60 yrs.

Exclusion Criteria

Patient not willing to participate in the study Patient with the history of difficult intubation Patient with anticipated difficult airway Patient having BMI>30kg/m2 Patient having history of cardiovascular, cerebral, renal, hepatic, bronchial, endocrine disease or psychiatric disorder Patient on anti-hypertensive, hypnotic or narcotic drugs.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in SBP following laryngoscopy and intubation in the two groups	Preoperative (base line values) i.e. before infusion of study drug \| During medication at 5min, 10min \| Pre-induction of anaesthesia \| Just before laryngoscopy and intubation \| Post intubation at 1 min, 3min, 5min, 7min and 10min \| Then every 5 min till the end of surgery

Secondary Outcome Measures

Name	Time	Method
To compare the heart rate between two groups following laryngoscopy and intubation	To compare Diastolic and Mean blood pressure between two groups

Trial Locations

Locations (1): UCMS and GTB Hospital
🇮🇳
East, DELHI, India
UCMS and GTB Hospital
🇮🇳East, DELHI, India
Kusum
Principal investigator
9354069382
mamacsinghkusum92@gmail.com