Clinical Outcomes of Cesarean Scar Pregnancy With Different Type: a Prospective Cohort Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Enrollment
- 500
- Primary Endpoint
- Incidence of blood loss
Study Overview
Brief Summary
This study is a prospective cohort study, led by Prof. Zhao Yangyu, from the Department of Gynecology & Obstetrics, Peking University Third Hospital.
Detailed Description
Cesarean section, myomectomy and other surgeries for uterus are likely to cause scars in different parts of the uterus. During the subsequent pregnancy, the incidence rate of cesarean scar pregnancy, placenta previa, placenta increta and the risk of termination of the first and mid-trimester pregnancy is likely to increase. Cesarean scar pregnancy is regarded as a risk factor of uterine rupture in the third trimester of pregnancy or delivery period, which severely affects the maternal and perinatal health and safety. This study is planning to prospectively include pregnant women aged 20-49 years from Peking University Third Hospital. All women with diagnosis on cesarean scar pregnancy was included prior to 14 wks of gestation. We divided the women into three different groups: type I, type II and type III according to characteristics in gestation sac,uterine scar, bladder, the latter with potentially worse outcomes in term of maternal morbidity and mortality. Data including demographics, medical history, reproductive history, prenatal health care, gestational complications, and pregnancy and birth outcomes will be collected via electronic data capture system.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 20 Years to 49 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Female aged ≥ 20 years
- •Female with cesarean scar pregnancy
- •Less than 14 gestational weeks
- •Planning to receive prenatal healthcare and delivery service at the study hospital
Exclusion Criteria
- •Inability to provide informed consent
- •Women with mental disorders
Outcomes
Primary Outcomes
Incidence of blood loss
Time Frame: delivery
blood loss
Incidence of perinatal death
Time Frame: 42 days postpartum
perinatal death
Incidence of postpartum hemorrhage
Time Frame: delivery
postpartum hemorrhage
Incidence of spontaneous abortion
Time Frame: delivery
spontaneous abortion
Incidence of maternal transfusion
Time Frame: delivery
maternal transfusion
Incidence of stillbirth
Time Frame: delivery
stillbirth
Secondary Outcomes
- Maternal death(42 days postpartum)
- The rate of repeated cesarean delivery(At delivery)
Investigators
Zhao Yangyu
Chief of obstetrics
Peking University Third Hospital
