The Application of Rapid PTH Test Paper in Operation of Hyperparathyroidism
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Serum PTH
研究概览
简要总结
The half-life of the parathyroid hormone is about 4min, blood pth test is use in operation to confirm that parathyroid tumor is removed. but the blood pth test is time consuming and unpractical in most of hospital. this study will compare the application of rapid PTH test paper in operation of hyperparathyroidism.PTH test were measured in operation in different way. it will test at the time of preoperation, 15 minutes after surgery, 1 hour after surgery and 24 hours after surgery. thus evaluate the reliability and accuracy of PTH test paper in evaluating the Miami principles with the linear relation of blood PTH and the PTH test paper method.
详细描述
Primary hyperparathyroidism is a clinically common disease. At present, the gold standard for determining whether the operation is successful is based on the Miami principle. That means The PTH hormone decreased to 30% of the baseline level after 15min after the tumor was removed. However, due to the differences in PTH monitoring conditions in various hospitals, many hospitals cannot perform rapid PTH monitoring in the operation. Therefore many doctors choose rapid freezing pathology to confirm the lesion., This also led to the inability to evaluate PTH in the presence of multiple lesions,and resulting in the need for reoperations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary hyperthyroidism.
- •Secondary hyperthyroidism
- •Unilateral thyroidectomy.
- •Total thyroidectomy and bilateral central compartment dissection
排除标准
- •age Older than 70 or younger than 18.
结局指标
主要结局
Serum PTH
时间窗: 0 minutes, 15 minutes, 1 hour and 24 hours post operation
Routine serum PTH test, using immunoluminescence.
PTH test paper
时间窗: 0 minutes, 15 minutes, 1 hour and 24 hours post operation
PTH test paper test for blood
Serum calcium
时间窗: 0 minutes, 15 minutes, 1 hour and 24 hours post operation
Routine serum electrolyte detection.
次要结局
未报告次要终点
研究者
Bo Wang,MD
Clinical professor
Fujian Medical University