Releasing of Inflammatory Mediators During Retreatment of Root Canals

Not Applicable

Completed

• Conditions: Inflammatory Response; Root Canal Infection
• Interventions: Other: Reciproc; Other: XP-Endo finisher R; Other: Protaper Universal Retreatment

• Registration Number: NCT05039502
• Lead Sponsor: Bulent Ecevit University

Brief Summary

Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper Universal Retreatment (PTUR), Reciproc blue and XP-endo Finisher R file systems, which are used in the removal of root canal filling materials during retreatment with different motion kinetics on the release of Substance P, Calcitonin Gene-Related Peptide (CGRP), IL-6 and IL-10 inflammatory mediators in the periapical region

Detailed Description

Seventy-five individuals with asymptomatic and chronic apical periodontitis teeth with retreatment indication were included in the study. Individuals were randomly divided into three groups according to the file system used to remove root canal filling materials (n = 25): ProTaper Universal Retreatment, Reciproc blue and XP-endo Finisher R.After the removal of the previous root canal filling materials, reshaping and disinfection of the root canals, periapical fluid samples were taken from the root tip of the teeth in all three groups. The amount of Substance P, CGRP, IL-6 and IL-10 mediators that cause pain, swelling and flare-up in periapical fluid samples were measured by ELISA test.

Study Timeline

• Study Start: 2020-10-01
• Primary Completion: 2021-03-15
• Study Completion: 2021-06-01
• Study First Submitted: 2021-08-31
• Status Verified: 2021-09
• Study First Submitted QC: 2021-09-02
• Last Update Submitted: 2021-09-02
• Study First Posted: 2021-09-09
• Last Update Posted: 2021-09-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

• Patients who had single root canal treated teeth with chronic periapical lesion

Exclusion Criteria

• Patients who are immunocompromised
• Patients under antibiotic or analgesic medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Retreatment system using in reciprocal motion	Reciproc	Previous root canal filling materials were removed with Reciproc 25 file with using an endodontic motor in reciprocal motion
Retreatment system using in additional rotational motion	XP-Endo finisher R	Previous root canal filling materials were removed with XP-endo finisher r file with using an endodontic motor in rotational motion
Retreatment system using in rotational motion	Protaper Universal Retreatment	Previous root canal filling materials were removed with D1-D2-D3 retreatment files with using an endodontic motor in rotational motion

Primary Outcome Measures

Name	Time	Method
change of inflammatory mediator level	24 hours	The samples were collected from periapical exudate at the end of the root canal retreatment procedure. The samples were analyzed with ELISA method and change of inflammatory mediator levels were evaluated in pg/ml.

Trial Locations

Locations (1)

Faculty of Dentistry of Bulent Ecevit University; 🇹🇷 Zonguldak, Turkey