NL-OMON51839
Recruiting
Not Applicable
Immune checkpoint inhibition associated cardiovascular adverse events in cancer patients - ITHACA
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- cardiovascular disease (CVD)
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 214
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Adult male or female, age \>\=50 years
- •\- Prior to start therapy
- •\- Confirmed diagnosis of cancer:
- •\- Treatment\-naive advanced esophageal, gastric, or gastro\-esophageal cancer
- •planned for first\-line nivolumab or chemotherapy only or follow\-up only after
- •\- Treatment\-naive advanced colorectal cancer planned for first\-line
- •pembrolizumab or other systemic therapies
- •\- Recurrent or metastatic head/neck squamous cell carcinoma with disease
- •progression during platinum\-based chemotherapy who are planned for
- •pembrolizumab or other systemic therapies
Exclusion Criteria
- •ICI therapy in previous 12 months;
- •Suspected or confirmed viral, fungal, or bacterial infectious disease;
- •Use of immunosuppressive therapy prior to ICI start;
- •Estimated glomerular filtration rate (eGFR) \<30 mL/min/1\.73m2;
- •Known allergy to iodinated contrast agents;
- •Atrial fibrillation
Outcomes
Primary Outcomes
Not specified
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