Early statin treatment in patients with acute coronary syndrome: The best intensive LDL-cholesterol lowering therapy is sought by two different regimens during half a year treatment using Volumetric Intravascular Ultrasound Analysis (ESTABLISH-2 study)
Not Applicable
- Conditions
- To asses the efficacy of two different regimens of intensive LDL-cholesterol lowering therapy with statin or statin and ezetimibe on the plaque volume and plaque morphology in patients with acute coronary syndrome during 6 months.
- Registration Number
- JPRN-UMIN000006593
- Lead Sponsor
- Juntendo University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 126
Inclusion Criteria
Not provided
Exclusion Criteria
A case of failed PCI diseased bypass graft recommended CABG cardiogenic shock A case of administration of other lipid-lowering drugs (clofibrate, probucol, nicotinic acid, or other prohibited drug without ezetimibe).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The percent change in plaque and vessel volume in non-culprit lesion on IVUS analysis during 6 months after onset of ACS.
- Secondary Outcome Measures
Name Time Method Correlation between the percent change in plaque volume and the biomarkers including LDL-cholesterol level. Major adverse cardiovascular event