The effects of berberis integerrima extract on the non-alcoholic fatty liver disease (NAFLD)
Not Applicable
Not yet recruiting
- Conditions
- on-alcoholic fatty liver disease (NAFLD).Nonalcoholic steatohepatitis (NASH)K75.81
- Registration Number
- IRCT20210427051098N6
- Lead Sponsor
- Yazd University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Age 18 and older
Diagnosis of the disease by ultrasound with a standard method
ALT >30 IU/L in men and ALT >19 IU/L in women
BMI higher than 18.5 and less than 30
Exclusion Criteria
Taking corticosteroids
Pregnancy and breastfeeding
Alcohol consumption (men: ethanol > 140 g per week, women: ethanol > 70 g per week)
History of diseases including liver cirrhosis, viral hepatitis, cardiovascular diseases, cancer
Medication history including corticosteroids, non-steroidal anti-inflammatory drugs, drugs affecting blood sugar, lipid profile, body weight and liver function.
Disease relapse and patient hospitalization
Barberry allergy
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Serum levels of alanine transaminase enzyme. Timepoint: Before intervention- after intervention (12 weeks after receiving barberry extract or placebo). Method of measurement: Enzymatic method.
- Secondary Outcome Measures
Name Time Method