Comparison of Upper Extremity Functional Performance in Hemophilic and Healthy Children

• Conditions: Hemophilia; Upper Extremity; Strength; Performance; Children

• Registration Number: NCT06826209
• Lead Sponsor: Hacettepe University

Brief Summary

The goal of this observational study is to evaluate the functional performance of the upper extremity joints (scapula, shoulder, elbow, and wrist) in haemophilic children and compare muscle strength and ADL limitations with healthy children.

Detailed Description

This study aims to evaluate the upper extremity functional performance, muscle strength, and daily living activity levels of hemophilic children and compare them with healthy children. The goal is to determine the effects of hemophilia on these children and contribute to the development of appropriate rehabilitation strategies. Parameters include explosive strength, isometric muscle strength, wrist grip strength, and functional exercise capacity. Additionally, the ADL-Glittre pediatric version test and Hemophilia Joint Health Score (HJHS) will be used to assess joint health and GYA performance. Muscle strength is crucial for hemophilic children to perform daily activities, and the relationship between muscle strength and GYA levels will be investigated. The project aims to guide the development of physiotherapy and rehabilitation strategies for hemophilic children and contribute to the literature by filling existing gaps, ultimately creating an important reference for healthcare professionals and families.

Study Timeline

• Study Start: 2024-10-24
• Status Verified: 2025-02
• Study First Submitted: 2025-02-06
• Study First Submitted QC: 2025-02-12
• Last Update Submitted: 2025-02-12
• Study First Posted: 2025-02-13
• Last Update Posted: 2025-02-13
• Primary Completion: 2026-06-24
• Study Completion: 2026-10-24

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• Diagnosed with Hemophilia A or B
• Receiving prophylaxis treatment (a routine treatment)
• Negative for inhibitors at the time of enrollment

Exclusion Criteria

• Positive for inhibitors at the time of enrollment
• Acute elbow bleeding
• History of acute muscle bleeding
• History of surgery in any upper extremity joints
• Having undergone radionuclide synovectomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hemophilia Joint Health Score	Through study completion, an average of 1 year	The Hemophilia Joint Health Score (HJHS) is a clinical tool used to assess joint health in individuals with hemophilia, focusing on major joints such as the knees, elbows, and ankles. It evaluates symptoms like pain, swelling, and range of motion restrictions, with a grading system that helps determine the severity of joint damage. The HJHS also considers joint function in daily activities, making it an essential tool for monitoring joint health and the progression of hemophilic arthropathy. It plays a vital role in both clinical management and research, helping guide treatment strategies and assess their effectiveness.

Secondary Outcome Measures

Name	Time	Method
Muscle Strength	Through study completion, an average of 1 year	The Lafayette Handheld Dynamometer is a device used to measure upper extremity muscle strength in children with hemophilia. It assesses muscle strength under isometric conditions and is typically used to test the muscles around the shoulder, elbow, and wrist. The measurements aim to determine the maximum force exerted by the muscles, which is important for identifying potential reductions in muscle strength in individuals with hemophilia. This test is valuable for determining physical performance levels, planning treatment approaches, and guiding rehabilitation processes.

Trial Locations

Locations (1)

Hacettepe Universit; 🇹🇷 Ankara, Turkey