Comparison of epidural morphine and dexamethasone to control pain following lumbar spine surgeries: a double blinded, randomized control study
Not Applicable
Completed
- Conditions
- Health Condition 1: G55- Nerve root and plexus compressionsin diseases classified elsewhere
- Registration Number
- CTRI/2020/02/023316
- Lead Sponsor
- All India Institute of Medical Sciences Jodhpur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
Inclusion Criteria
60 patients
Scheduled for single level lumbar discectomy
Exclusion Criteria
Participant refusal
Allergic to study drugs
Cervical or thoracic level laminectomies
Spine-fixation surgery
History of previous spine surgery
Neuromuscular disease
Psychological disease
Inability to understand visual analog scale (VAS)
Systemic use of steroids
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the analgesic property of gelfoam soaked epidural morphine with gelfoam soaked epidural dexamethasone following discectomy in 24 hours postoperative follow up.Timepoint: 24 hours postoperative follow up.
- Secondary Outcome Measures
Name Time Method Any adverse event related to study drugs or surgery.Timepoint: 24 hours postoperative follow up.
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie epidural morphine and dexamethasone's analgesic effects after lumbar discectomy?
How does epidural morphine compare to dexamethasone in postoperative pain control for lumbar spine surgeries versus standard-of-care analgesics?
Which biomarkers correlate with improved analgesic response to epidural morphine or dexamethasone in lumbar discectomy patients?
What are the adverse event profiles of epidural morphine and dexamethasone in post-lumbar discectomy pain management, and how are they mitigated?
Are there combination therapies involving epidural morphine and dexamethasone that enhance analgesia in lumbar spine surgery compared to monotherapy?