Effects of open- and closed label nocebo and placebo verbal suggestions on itch
Completed
- Conditions
- Het onderzoek wordt bij gezonde proefpersonen uitgevoerd. Uitkomsten uit deze lijn van onderzoek bieden nieuwe handvatten voor verklaringsmodellen en therapeutische interventies voor aandoeningen waarbij jeuk een symptoom is.Not applicable
- Registration Number
- NL-OMON43008
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 92
Inclusion Criteria
Between 18 and 35 years old; good understanding of written and spoken Dutch
Exclusion Criteria
Refusal to give written informed consent; severe somatic or psychological morbidity (e.g., heart and lung diseases or DSM-IV psychiatric disorders) that would adversely affect participant's safety or that might interfere with the study protocol; current chronic itch or pain complaints; current use of analgesics, anti-inflammatory drugs, antihistamines, antibiotics or recent vaccinations; pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameter is self-reported itch during histamine<br /><br>iontophoresis. </p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study outcomes include wheal size, flare response, skin temperature,<br /><br>and self-reported skin condition following histamine iontophoresis, as well as<br /><br>scratching behaviour. In addition, the possible influence of psychological<br /><br>parameters on outcomes will be explored.</p><br>