JPRN-jRCTs031180337已完成未知
The effects of galantamine administration on brain network topology in patients with Alzheimer's disease (AD): A possible new biomarker for pharmacotherapy of AD
Hanakawa Takashi0 个研究点目标入组 9 人开始时间: 2019年3月18日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 9
研究概览
简要总结
We evaluated pharmacological effects of the galantamine, which is an acetylcholinesterase inhibitor, onto brain networks in patients with Alzheimer's disease patients. A network analysis utilizing a topological analysis found an influence of galantamine administration onto functional connectivity in comparison with a placebo control condition. However, the sample size (n = 4) was limited, we need to exercise caution to extend the inference to the population.
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- >= 20age old 至 ot applicable（—）
- 性别
- All
入选标准
- •A diagnosis of probable AD according to criteria of the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association (NINCDSADRDA) with Mini-Mental State Examination (MMSE) scores between 10 and 25.
排除标准
- •1) Co-existing other neurodegenerative disease.
- •2) A history indicating excessive nicotine or alcohol intake (>0.5 packs of cigarettes, >4 glasses of an alcoholic substance a day), a severe allergy to pharmacological substances or their constitutive compounds, or the use of any experimental medication within 3months prior to the enrolment in the trial.
- •3) Patients with cardiovascular disease (e.g. myocardial infarction, valvulitis, or cardiomyopathy) or electrolyte imbalance (e.g. hypokalaemia).
- •4) Patients with severe liver dysfunction (Child-Pugh score of C) or severe renal dysfunction.
- •5) Exclusion criteria to MRI: presence of a pacemaker, metallic implants in high-risk areas (i.e. aneurysm clips) and a history of claustrophobia
研究者
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