Positioning and Gastric Aspiration in Ventilated Premature Infants
Not Applicable
Completed
- Conditions
- Respiratory Aspiration of Gastric Contents
- Interventions
- Behavioral: Right side position
- Registration Number
- NCT02016651
- Lead Sponsor
- Cairo University
- Brief Summary
Gastro-esophageal reflux and aspiration is a common problem in premature infants receiving mechanical ventilation. Pepsin measured in tracheal aspirate (TA) emerged as a specific marker for aspiration. The objective of this study is to examine if TA pepsin will change when ventilated premature infants are positioned in two different positions; on their back vs. on their right side.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 34
Inclusion Criteria
- Infants born between 28 and 32 weeks gestational age
- postnatal age > 72 hours
- tracheally intubated and receiving conventional mechanical ventilation
- feeding enterally more than 20 ml per day.
Exclusion Criteria
- neurological insult in the form of perinatal asphyxia (pH <7, base deficit more than 12, Apgar score at < 3 at 5 minutes of life), intracranial hemorrhage grades 3 or 4 at 72 hours of age or periventricular leucomalacia
- major congenital anomalies, or gastrointestinal anomalies such as tracheoesophageal fistula, or necrotizing enterocolitis ,
- receiving xanthine derivatives, H2 blockers, prokinetics, proton pump inhibitors or sedation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Right side position Right side position Premature infants on mechanical ventilation are kept on their right side
- Primary Outcome Measures
Name Time Method Pepsin concentration in tracheal aspirate 6 hours after intervention
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Cairo University Children's Hospital
🇪🇬Cairo, Egypt