NCT06648317招募中不适用
Radiolabelled Nectin-4 Targeted LMW Probe PET/CT in Patients With Lung Lesions
Peking University Cancer Hospital & Institute1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2024年11月21日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Standardized uptake value（SUV）
研究概览
简要总结
To evaluate the ability of [68Ga]N188 to detect nectin-4 overexpression in patients with lung lesions.
详细描述
To evaluate the ability of [68Ga]N188 to detect nectin-4 overexpression in patients with different lung lesions, such as inflammation and lung cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18-75 years old, male or female;
- •Heart function is normal;
- •Normal heart function;
- •Estimated survival ≥12 weeks;
- •Good follow-up compliance;
- •presence of at least one measurable target lesion according to RECIST1.1 criteria;
- •Women of childbearing age (15-49 years) must have a negative pregnancy test within 7 days before starting the test; Fertile men and women must agree to use effective contraception to prevent pregnancy during the study period and for 3 months after the test;
- •Patients recommended by clinicians to undergo PET/CT examination for tumor diagnostic staging;
- •The subject patients could fully understand and voluntarily participate in the experiment, and signed the informed consent.
排除标准
- •Serious abnormality of liver, kidney and blood;
- •Pregnant patients;
- •Pregnant and lactation women;
- •unable to lie flat for half an hour; 4) Refuse to join the clinical investigator; 5) Suffering from claustrophobia or other mental diseases; 6) Other conditions that researchers deem unsuitable for participating in the experiment.
结局指标
主要结局
Standardized uptake value（SUV）
时间窗: 1 year
SUV is a semi-quantitative analysis index to describe the radioactive uptake of lesions, which has certain reference value for differentiating benign and malignant lesions. The uptake of the tracer （68Ga-N188） in lung lesions by measuring SUV on PET/CT.
次要结局
未报告次要终点
研究者
nanli
Professor
Peking University Cancer Hospital & Institute
研究点 (1)
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