Role of magnetic resonance spectroscopy in spinal cord lesions with clinical and / or histopathological correlation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Significant correlation between findings of MR spectroscopy and clinical or histopathological findings of spinal cord lesions.
研究概览
简要总结
INTRODUCTION
The spinal cord contains a variety of lesions, both non-neoplastic and neoplastic. Magnetic resonance spectroscopy (M.R.S.) is a non-invasive method for analyzing the chemical composition of human tissue. As a result, it contributes to a better understanding of pathological conditions affecting the spinal cord and provides important biomarkers for diagnostic purposes. Magnetic Resonance spectroscopy provides insights into cellular composition, tissue integrity, and metabolic activity through the analysis of metabolite levels, guiding differential diagnosis and therapeutic decisions. Correlating M.R.S. findings to clinical presentation and histopathological analysis improves diagnostic accuracy and informs prognosis.
A.I.M.
To assess spinal cord lesions using M.R.S. (magnetic resonance spectroscopy) and correlate the results clinically and/or histo-pathologically.
OBJECTIVES
-
To evaluate the spectrum of spinal cord lesions using magnetic resonance imaging.
-
To ascertain the magnitude of peaks of various metabolites in patients with intramedullary and extramedullary spinal cord lesions using magnetic resonance spectroscopy sequences.
-
To correlate the interpreted magnetic resonance spectroscopy findings clinically or histo-pathologically.
METHODS
The study involves a sample of 33 patients. It employs a prospective cross-sectional approach who come to A.V.B.R.H. associated with Jawaharlal Nehru Medical College, Sawangi (Meghe), Wardha, in the interval of December 2023 and December 2025. Magnetic resonance spectroscopy will be done in patients with spinal cord lesions under the inclusion criteria. Using statistical methods, M.R.S.’s role as an adjunct diagnosis tool will be found.
OUTCOME MEASURES
The outcome will demonstrate the practical impact of Magnetic Resonance Spectroscopy, which, when combined with clinical and histopathological information, can help in the accurate diagnosis of spinal cord lesions.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Day(s) 至 95.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with spinal cord lesions on M.R. imaging.
排除标准
- •Patients with metal implants or foreign bodies in their eyes, pacemakers, Claustrophobic patients, Uncooperative and non-consenting patient.
结局指标
主要结局
Significant correlation between findings of MR spectroscopy and clinical or histopathological findings of spinal cord lesions.
时间窗: Assessment will be done at the end of 18 months.
次要结局
未报告次要终点
研究者
Dr Saraswathula L G V R Bharadwaj
Datta Meghe Institute of Higher Education and Research