IRCT20180803040681N1已完成2 期
A randomized controlled trial on the efficacy and safety of Metformin in severe traumatic brain injury
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 years 至 65 years（—）
- 性别
- All
入选标准
- •a definite diagnosis of head trauma
- •GCS score of 8 or less
- •patients on mechanical ventilator
- •written informed consent signed by patient’s legal guardian
排除标准
- •time of admission to ICU of more than 48 hours
- •Per Os (NPO) status on admission day
- •previous treatment with metformin or any other biguanide medication
- •blood glucose level of =150mg/dL or =70mg/dL
- •simultaneous participation in another clinical trial
- •serum creatinine level of 1.5mg/dL or more
- •serum lactate level of 2.5mmol/L or more
- •arterial pH of less than 7.25
- •serum bicarbonate of 13mEq/L or less
- •moderate to severe renal impairment (estimated glomerular filtration rate (eGFR) of below 45mL/min/1.73m2)
- •acute liver failure
研究者
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