An observational study to evaluate driving competence in Huntington's disease - Evaluating driving competence in HD (Drive-HD)

Centre for Human Drug Research0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

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•All eligible subjects must meet the following inclusion criteria:
•- be at least 18 years of age;
•- possess a valid Dutch driver's licence;
•- driven at least 300 km in the 12 months prior to study entry, to ensure regular driving activity.;Additional inclusion criteria HD manifest subjects
•- confirmed CAG expansion of *36 in the HTT gene;
•- UHDRS TMS >5.;Additional inclusion criteria for HD premanifest gene carriers
•- confirmed CAG expansion of *36 in the HTT gene;
•- UHDRS TMS *5, and no diagnosis in any other HD related domain (i.e. cognition or psychiatric).;Additional inclusion criteria for control subjects
•- Gene negative for HD or no family history of HD, preferably spouses or relatives of HD subjects.

•All eligible subjects must meet none of the following exclusion criteria:
•- Major comorbidities that are unrelated to HD (i.e. isolated psychiatric disorder, other neurological disorder, paralysis, ophthalmic disorder);
•- Drug use (i.e. not medication) in the past 3 till 4 weeks prior to the visit day;
•- Alcohol abuse (i.e. 3 or more glasses per day);
•- Participation in intervention/clinical trials;
•- Any other condition that in the opinion of the investigator warrants exclusion of the study.

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