The Chronic Effects of Low-Load Blood Flow Restriction or Standard of Care Resistance Exercise on Muscle and Neuromuscular Function in Patients With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Change in Functional Outcomes- CST
研究概览
简要总结
This research is being done to compare the current standard of care for strength training for patients with Multiple Sclerosis to lightweight resistance training with blood flow restriction.
详细描述
The purpose of this study is to compare the effectiveness of the current Multiple Sclerosis standard of care exercise recommendations to low-load resistance training with blood flow restriction on functional outcomes, strength, muscle size, and neuromuscular control in Multiple Sclerosis patients. This study involves completing 2 training sessions per week for 12 weeks as well as pre- and post-training assessment visits for a total of 29 visits over 14 weeks. All visits will be on UCF's campus with a member of the research team.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
盲法说明
Participants and Investigators will be aware of treatment groups
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Females between the ages of 18 to 55
- •Diagnosed with Multiple Sclerosis
- •Expanded Disability Status Score of 0 to 6.5
- •Able to walk 10 meters without assistance
- •Are willing to come in for all 29 testing visits over 14 weeks
排除标准
- •No other known cardiovascular, pulmonary, metabolic, muscular, and/or coronary heart disease
- •Multiple Sclerosis relapse in the past 30 days
- •Are not currently undergoing a rehabilitation protocol
- •Are not currently seeking medical care for a chronic condition that could limit exercise capacity other than multiple sclerosis
- •Are not currently pregnant
研究组 & 干预措施
Blood Flow Restriction
The BFR group will complete 1 set of 30 (1 x 30) at 30% of their 1 repetition maximum for leg press, leg extension, leg curl, chest press, seated row, and shoulder press completed on exercise machines with 2 minutes between exercises.
干预措施: Blood Flow Restriction (Other)
Standard of Care
The standard of care group will complete 1 set of 8-12 repetitions at 60-80% of their 1 repetition maximum for leg press, leg extension, leg curl, chest press, seated row, and shoulder press completed on exercise machines with 2 minutes between exercises.
干预措施: Standard of Care (Other)
结局指标
主要结局
Change in Functional Outcomes- CST
时间窗: Day 2, Week 4 and 8, Day 28
determined via changes in sit-to-stand test, measured by how quickly someone can stand from a seated position
Change in Functional Outcomes- 6min walk
时间窗: Day 2, Week 4 and 8, Day 28
determined via changes in 6 minute walk test, measured by how far (in feet) someone can walk in 6 minutes
Change in Functional Outcomes- MFIS
时间窗: Day 2, Week 4 and 8, Day 28
determined via changes in Modified Fatigue Impact Scale Questionnaire, sum score of answers on the questionnaire
Change in Functional Outcomes- 10meter
时间窗: Day 2, Week 4 and 8, Day 28
determined via changes in 10 meter walk test, measured by how fast (in minutes and seconds) someone can walk 10 meters
Change in Functional Outcomes- 30CST
时间窗: Day 2, Week 4 and 8, Day 28
determined via changes in 30 second sit-to-stand, measured by how many times someone can stand from a seated position in 30 seconds
次要结局
- Changes in Strength(Day 3, Week 4 and 8, Day 29)