Dexmedetomidine versus Nitroglycerine infusion for hypotensive anaesthesia in FESS

Not yet recruiting

• Conditions: Medical and Surgical, (2) ICD-10 Condition: O||Medical and Surgical,

• Registration Number: CTRI/2021/05/033541
• Lead Sponsor: DR SMITUL DAVE

Brief Summary

Total 60 adult patients of either sex of ASA physical status I / II will be included in the study. After thorough preoperative assessment of all patients, informed consent will be  taken from each patient. All patients will be  premedicated with inj. Fentanyl 2 microgram/kg, inj. Glycopyrolate 0.004 mg/kg, inj. Ondansetron 4mg. Intravenously. All patients will be induced with inj. Thiopentone sodium 6 mg/kg and inj. Succinylcholine 1.5 mg/kg. Oral intubation with proper size tube and packing will be done. Anaesthesia will be maintained with oxygen and nitrous oxide mixture( 50 : 50) + Sevoflurane ( 2% dial concentration) + inj. Atracurium. All patients will be  placed in Reverse Trendenburg position( 15 degree head up) after induction. Group D : Patients will receive inj. Dexmedetomidine 1 microgram/kg iv as a bolus dose over 10 minutes then followed by infusion at the rate of 0.3 - 0.5 microgram/kg/hour. Group N : Patients will receive inj. Nitroglycerine as a continuous infusion in dose of 0.5 – 5microgram/kg/hour. All patients will be  observed for Non Invasive Blood pressure, Heart rate, MAP and oxygen saturation at frequent intervals till the end of surgery. Surgical field quality will be  assessed by predefined category scale adopted from FROMM AND BOEZAART SCALE ( AVERAGE CATEGORY SCALE) .Recovery profile using Ramsay sedation score and Post op analgesia using VAS will be assessed hourly upto 6 hours. The collected data will be subjected to statistically analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-17
• Last Update Posted: 2021-10-05

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

ASA I and II undergoing FESS.

Exclusion Criteria

Patients with known allergy to drugs to be used, Pregnant and lactating women, History of chronic hypertension/ Sinus bradycardia, Patient refusal.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
quality of surgical field	2 hours

Secondary Outcome Measures

Name	Time	Method
1. Recovery profile	2. Post op analgesia

Trial Locations

Locations (1)

SRI LAKSHMI NARAYANA INSTITUTE OF MEDICAL SCIENCES; 🇮🇳 Pondicherry, PONDICHERRY, India

SRI LAKSHMI NARAYANA INSTITUTE OF MEDICAL SCIENCES

🇮🇳Pondicherry, PONDICHERRY, India

Smitul Dave

Principal investigator

9408115792

smitul1511@gmail.com