The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary Syndrome

• Conditions: Frail Elderly Syndrome; ACS; Elderly Patient

• Registration Number: NCT04580706
• Lead Sponsor: Beijing Friendship Hospital

Brief Summary

This is a prospective observational clinical trail which will recruit 1000-1500 participants over 65 years with frailty and acute coronary syndrome (ACS) in Beijing Friendship hospital. The investigators will conduct frailty assessment (FRAIL scale, CFS, SPPB), comorbidities, functional status (Barthel index, ADL, IADL), nutritional risk (MNA-SF), and then observe the clinical outcomes of elderly ACS participants with frailty. Then, the investigators will follow-up these participants separately in 1,3,6 and 12months, the anticipate follow-up time is 1 year. According to the follow-up results, investigators will evaluate the impact of frailty and other senile syndromes on the short-term and long-term prognosis of ACS, and develop a scoring system for the prognosis evaluation of elderly ACS participants.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-01-01
• Study First Submitted: 2020-09-11
• Status Verified: 2020-10
• Study First Submitted QC: 2020-10-07
• Last Update Submitted: 2020-10-07
• Study First Posted: 2020-10-08
• Last Update Posted: 2020-10-08
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 1000

Inclusion Criteria

• Elderly participants over 65
• Clinical diagnosis of acute coronary syndrome
• Must be able to follow-up
• Sign in the informed consent

Exclusion Criteria

• Myocardial infarction caused by other acute disease
• Mental disorders who cannot cooperate to complete the assessment
• Severe liver dysfunction, kidney disease (CKD 5), end-stage malignant tumor
• Totally disabled and bedridden

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Death	1 year	All-cause death and cardiac death events
Major Adverse Cardiac and Cerebrovascular events	1 year	Major Adverse Cardiac and Cerebrovascular events including heart failure, cardiac shock, malignant arrhythmia, myocardial infarction, revascularization, and cerebral infarction

Trial Locations

Locations (1)

Beijing Friendship hospital; 🇨🇳 Beijing, Beijing, China