Comparison between leflunomide or methotrexate plus subcutaneous tumour necrosis factor-alpha (TNF-alpha) blocking agents in rheumatoid arthritis: a two year open label study

St John of God Hospital (Ospedale S. Giovanni di Dio) (Italy)0 个研究点目标入组 96 人开始时间: 2010年7月6日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Adult patients (aged between 26 and 86 years, either sex) with active rheumatoid arthritis (RA) defined as follows: greater than or equal to 6 swollen joints and greater than or equal to 6 painful joints and at least two of the following:
•1.1. Morning stiffness greater than or equal to 45 minutes
•1.2. Erythrocyte sedimentation rate (ESR) greater than or equal to 28 mm/first hour
•1.3. C-reactive protein (CRP) greater than or equal to 2.0 mg/dL
•2. Stabilised low-dose of prednisone (less than or equal to 7.5 mg )
•3. Stable dose of non-steroidal anti-inflammatory drugs (NSAIDs)
•4. Intrarticular injections of corticosteroids not allowed

•Patients in stable therapy with LEF or MTX with a non-controlled disease activity with association therapy using a biological infusion (infliximab, rituximab, abatacept) or with a high dose of prednisone (greater than 10 mg)

发起方

St John of God Hospital (Ospedale S. Giovanni di Dio) (Italy)