Measuring limb perfusion with Near Infrared Spectroscopy (NIRS), Cellular Oxygen METabolism (COMET) and Dynamic Light Scattering (DLS) during Minimally Invasive Cardiac Surgery (MICS)
Completed
- Conditions
- 1000759310047079Leg ischemia / Limb hypoperfusion
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 43
Inclusion Criteria
- 18 years or older
- Acceptable proficiency of the Dutch or English language
- ASA 2-4
- Minimally invasive cardiac surgery requiring cardiopulmonary bypass
Exclusion Criteria
- Absence of written informed consent
- Presence of mitochondrial disease
- Pregnancy/lactation
- Emergency surgery
- Patients with skin laesions on the lower extremities which impede
measurements
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>During surgery the tissue oxygen saturation, mitoPO2 and microcirculatory blood<br /><br>velocity will be measured continuously in the cannulated and non-cannulated<br /><br>limb.<br /><br>The main study parameter is the difference in mitoPO2 levels between the<br /><br>cannulated and non-cannulated leg and the difference in RBV measurements<br /><br>between these limbs, during cannulation, five minutes before end of CPB. </p><br>
- Secondary Outcome Measures
Name Time Method <p>- Difference in mitoPO2 levels between the cannulated and non-cannulated leg<br /><br>during the other flow alternating moments (before cannulation, start CPB, extra<br /><br>leg canula in case of ischaemia, end of CPB and after decannulation).<br /><br>- Difference in RBV measurements between the cannulated and non-cannulated leg<br /><br>during the other flow alternating moments (before cannulation, start CPB, extra<br /><br>leg canula in case of ischaemia, end of CPB and after decannulation).<br /><br>- Difference in response time of mitoPO2 and StO2.<br /><br>- Difference in response time of RBV and StO2.<br /><br>- Temperature (C) difference in both legs, as measured with the COMET probe.<br /><br>- Mean difference in flow as measured by the DLS sensor at the tube of the CPB<br /><br>pump and the flow of the CPB system</p><br>