Comparative study of topical Methotrexate gel(1%) vs Clobetasol propionate cream (0.05%) in palmoplantar psoriasis and chronic plaque psoriasis : An Open Label Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- EFFICACY AND SAFETY OF METHOTREXATE GEL IN TREATMENT OF PALMOPLANTAR PSORIASIS AND CHRONIC PLAQUE PSORIAISIS
研究概览
简要总结
Psoriasis does result in a lot of concern to thepatient because of the itching and cosmetic appearance.There are very fewstudies that have been conducted comparing various topical agents being usedfor palmoplantar psoriasis and chronic plaque psoriasis.The rationale of thisstudy is to compare one of the most commonly used topical steroid-clobetasolwith methotrexate gel,a topical form of oral drug that has been used fortreatment of psoriasis. The hypothesis for the research question is To compare theefficacy and safety of topical methotrexate gel (1%) in comparison toclobetasol propionate cream(0.05%) for the treatment of palmoplantar psoriasisand chronic plaque psoriasis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Other
- 盲法
- Open Label
入排标准
- 年龄范围
- 18.00 Year(s) 至 85.00 Year(s)（—）
- 性别
- All
入选标准
- •1.PATIENT WITH LESIONS COVERING >30% OF PALMS AND SOLES (PALMOPLANTAR PSORIASIS) OR CHRONIC PLAQUE PSORIASIS WITH INVOLVEMENT OF BODY SURFACE AREA <20% 2.PATIENT WHO GIVE THEIR CONSENT FOR THE STUDY 3.WOMEN IF WILLING TO AVOID CONCEPTION DURING THE STUDY AND FOR 4 MONTHS SUBSEQUENT TO THE STUDY.
排除标准
- •1.Patients of age <18 years 2.Involvement of >20% Body Surface Area where systemic therapy is needed 3.Pregnant/Breast feeding females.
- •4.Patients on NB-UVB 5.Patients who had taken topical antipsoriatic medication except bland emollients in 2 weeks or more before enrollment 6.Patients who had taken systemic antipsoriatic medication in 1 month or more before enrollment 7.Patients with haematological/renal/ hepatic dysfunction.
- •8.Patients who didn’t gave their consent for the study or have not shown willingness for follow up.
结局指标
主要结局
EFFICACY AND SAFETY OF METHOTREXATE GEL IN TREATMENT OF PALMOPLANTAR PSORIASIS AND CHRONIC PLAQUE PSORIAISIS
时间窗: 8 WEEKS
次要结局
- ERYTHEMA, INDURATION, SCALING FOR PALMOPLANTAR PSORIASIS(PASI SCORE FOR CHRONIC PLAQUE PSORIASIS)