New Transporting Solution in Parathyroid Allotransplantation

Not Applicable

• Conditions: Parathyroid Allotransplantation
• Interventions: Drug: BAVU Solution

• Registration Number: NCT02978287
• Lead Sponsor: Sisli Hamidiye Etfal Training and Research Hospital

Brief Summary

The aim of this study is to measure of the parathyroid cell viability and the the amount of calcium sensing receptor of the parathyroid cells which were placed into a new transportation solution (BAVU solution) for parathyroid allotransplantation.

Detailed Description

The cold ischemia of organs, has harmful effects on the tissues due to oxidative stress and inflammation. This is physiopathologically defined as ischaemia/re-perfusion injury (IRI) in organ transplantation. Parathyroid allotransplantation has an increased popularity at the last decade. But the cold ischemia due to transportation of the transplant tissue is a very important problem.

Calcium sensing receptor plays a crucial role in regulating Parathormone secretion which means controlling of the calcium-dependent systemic ion homeostasis.

The investigators developed a new tissue transporting solution for parathyroid allotransplantation and the investigators measured the parathyroid cell viability and the the amount of calcium sensing receptor of the parathyroid cells at the 0., 6., 12. and 24. hours of the parathyroid cells which were placed into our new solution.

Study Timeline

• Study Start: 2016-09
• Status Verified: 2016-11
• Primary Completion: 2016-11
• Study First Submitted: 2016-11-24
• Study First Submitted QC: 2016-11-29
• Last Update Submitted: 2016-11-29
• Study First Posted: 2016-11-30
• Last Update Posted: 2016-11-30
• Study Completion: 2016-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

• Patients who have parathyroid hyperplasia due to chronic renal failure

Exclusion Criteria

• Patients who refused to join to the study
• Patients younger than 18 years and older than 80 years.
• Patients who have hepatitis B,
• Patients who have hepatitis C,
• Patients who have human immunodeficiency virus (HIV)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
BAVU Solution 6. hour	BAVU Solution	Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 6. hour
BAVU Solution 12. hour	BAVU Solution	Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 12. hour
BAVU Solution 18. hour	BAVU Solution	Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 18. hour
BAVU Solution 24. hour	BAVU Solution	Viability, Calcium sensing receptor and parathormone levels of Parathyroid cells at 24. hour

Primary Outcome Measures

Name	Time	Method
Cell viability of Parathyroid cells	24 hours	The investigators will measure the viability of Parathyroid cells at 24 hours at the BAVU solution

Trial Locations

Locations (1)

Bezmialem University; 🇹🇷 Istanbul, Turkey