Phase I Study Panitumumab Plus Chemoradiotherapy and Induction Chemotherapy in Patients With Locally Advanced Squamous Cell Cancer of the Head and Neck

Massachusetts General Hospital2 个研究点分布在 1 个国家目标入组 34 人开始时间: 2006年4月最近更新: 2017年3月1日

适应症

干预措施

试验速览

阶段: 1 期
状态: 已完成
发起方: Massachusetts General Hospital
入组人数: 34
试验地点: 2
主要终点: To identify the maximally tolerated dose of paclitaxel given with panitumumab plus carboplatin chemoradiotherapy.

研究概览研究设计入排标准研究组 & 干预措施结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study is being done to test whether panitumumab, in combination with chemotherapy and radiation is safe in people with head and neck cancer. Another goal of this study is to find the highest dose of the study drugs that can be given safely without causing serious sife effects. Panitumumab is a type of drug called a monoclonal antibody that has been studied in other types of cancers, such as kidney and colon. This monoclonal antibody is directed against the epidermal growth factor receptor (EGFR). EGFR has been found on the majority of head and neck cancer cells. By blocking EGFR, this monoclonal antibody may inhibit the growth of head and neck cancer cells.

详细描述

There are two parts to this study: Part A and Part B. Participants enrolled in Part A of this study received panitumumab and chemoradiotherapy. Participants enrolled in Part B will receive panitumumab in combination with induction chemotherapy followed by chemoradiotherapy.
The main purpose of Part A was to examine the safety and the best dosing of panitumumab, chemotherapy and radiation for the treatment of head and neck cancer. The best dosing was determined by increasing doses of chemotherapy given in combination with panitumumab during radiation. The chemotherapy drugs being used in Part A were carboplatin and paclitaxel, which are standard therapies used in head and neck cancer. These drugs were be added to radiation and this combination is called chemoradiotherapy. The investigators have determined the best dose of panitumumab and chemotherapy to give with radiation, Part B has now begun.
The main purpose of Part B is to examine the safety and best dosing of chemotherapy combined with panitumumab (called induction therapy) prior to receiving panitumumab and chemoradiotherapy. The drugs that are used for induction chemotherapy will be docetaxel, cisplatin and 5-fluorouracil. These drugs are also standard therapies used in head and neck cancer.

研究设计

研究类型: Interventional
分配方式: Non Randomized
干预模型: Parallel
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Histologically or cytologically proven squamous cell carcinoma of the head and neck or its variants (such as basaloid squamous cell carcinoma, undifferentiated carcinoma, or adenosquamous cell carcinoma). Primary tumor sites eligible include: nasopharynx, oral cavity, oropharynx, hypopharynx, larynx or unknown primary SCCHN
•Stage III or IV disease, without evidence of distant metastasis, according to American Joint Committee on Cancer
•Measurable disease, according to RECIST.
•No prior chemotherapy, radiotherapy or attempted complete resection of the SCCHN. Diagnostic biopsy, including excisional nodal biopsy and/or tonsillectomy is allowed if the subject has measurable disease at the time of enrollment
•18 years of age or older
•ECOG Performance Status of 0 or 1
•No active alcohol addiction or other condition that, in the opinion of the study investigators, would interfere with the subject's ability to comply with the treatment plan
•Adequate hepatic and renal function
•Women of childbearing potential must have a negative pregnancy test within 2 weeks of study entry.

排除标准

•Pregnant or breast feeding women
•Symptomatic peripheral neuropathy of grade 2 or higher by NCI CTCAEv3.0
•Grade 3 or more hearing loss
•History of other malignancy within the previous 5 years, except for nonmelanoma skin cancer, carcinoma in situ of the cervix, bladder or head and neck
•Prior radiation to head and neck
•Other serious illness or medical conditions
•Patients who experienced an involuntary weight loss of more than 20% of their body weight in the 2 months preceding study entry
•Concurrent treatment with any other anticancer therapy
•Prior therapy which affects or targets the ErbB pathway, including any inhibitors of EGFR and ErbB2
•Participation in an investigational drug trial within 30 days of study entry

研究组 & 干预措施

Part A

Experimental

Determine the best dosing of panitumumab, chemotherapy and radiation.

干预措施: Panitumumab (Drug)

Part A

Experimental

Determine the best dosing of panitumumab, chemotherapy and radiation.

干预措施: Carboplatin (Drug)

Part A

Experimental

Determine the best dosing of panitumumab, chemotherapy and radiation.

干预措施: Paclitaxel (Drug)

Part A

Experimental

Determine the best dosing of panitumumab, chemotherapy and radiation.

干预措施: Intensity Modulated Radiation Therapy (Radiation)