An evaluation of the effect of albumin administration time on the incidence of fluid creep in severe burn patients
- Conditions
- Burn.Burns classified according to extent of body surface involved
- Registration Number
- IRCT20210227050510N1
- Lead Sponsor
- Rasht University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 96
burn patients with 2nd and 3rd degree burn area more than 20 percent TBSA
full-thickness burn area more than 10 percent TBSA
patients needing vasopressor usage in the first 24 hours of admission
patients needing intubation and mechanical ventilation in the first 24 hours of admission
patients not needing albumin infusion according to the clinical decision of specialist
critically ill patients with expected death in first 24 hours or patients that expired in first 24 hours of admission
brain death in first 24 hours
patients admitted more than 8 hours after burn
patients with chronic underlying diseases affecting serum albumin level, including nephrotic syndrome, cirrhosis, malnutrition, exudative enteropathy
pregnancy
a history of cardiac surgery or myocardial infarction in recent 5 years
patients with high-voltage electrical burn injuries
patient does not accept entering the study
patients receiving plasmaphresis
a history of reaction to human albumin
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Fluid creep, patient's fluid intake exceeding estimated intake with parkland formula. Timepoint: 12 hours and 1,2,3,5, and 7 days after-burn. Method of measurement: assessment of the fluid intake of patient to maintain a satisfactory urine output.
- Secondary Outcome Measures
Name Time Method ength of hospital stay. Timepoint: At the time of hospital discharge. Method of measurement: Days.