NCT02464137终止1 期
A Phase I Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Advanced Laryngeal Cancer
适应症
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- toxicities
研究概览
简要总结
single-modality phase I dose escalation toxicity study for first-line curative treatment of head and neck squamous cell carcinoma.
详细描述
HYDRA will consist of 5 fraction SBRT treatment targeting only grossly evident disease localized by examination and standard diagnostic CT, MR, and PET-CT imaging. Prophylactic coverage of uninvolved at-risk mucosal and nodal drainage basins will be strictly disallowed. The initial dose cohort will be treated to a total of 42.5 Gy in five equal fractions delivered every other day over a two week period (biologically equivalent to 66 Gy delivered in 2 Gy daily fractions), drawn from our successful institutional experience with similar dosing and fractionation for early-stage larynx SBRT. Escalation of total dose will proceed in 2.5 Gy increments, up to a final target dose of 50 Gy.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 99 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 18 years of age with histologically proven squamous cell carcinoma of the larynx.
- •Stage T1-2N1-2c/T3-4N0-2c disease, as defined by American Joint Committee on Cancer (AJCC) criteria.
- •ECOG (Zubrod) performance status 0-
- •Must be functionally and technically fit for partial laryngectomy.
- •Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 90 days following completion of therapy.
- •Ability to understand and the willingness to sign a written informed consent
排除标准
- •Patients who have undergone resection of primary disease.
- •Patients who have received induction chemotherapy for their cancer diagnosis.
- •Patients who have undergone a diverting tracheostomy which is either a) traversing directly through tumor, b) has been placed for true airway insufficiency. Patients with a tracheostomy placed preemptively for impending airway compromise remain eligible for enrollment.
- •Prior cancer diagnosis, except appropriately treated localized epithelial skin cancer or cervical cancer.
- •Prior radiation therapy to the head and neck region.
- •Women of childbearing potential (a woman of child-bearing potential is a reproductively mature woman who has not undergone a hysterectomy or who has not been naturally postmenopausal for at least 24 consecutive months [i.e., who has had menses at any time in the preceding 24 consecutive months]) and male participants must practice effective contraception (oral, injectable, or implantable hormonal contraceptive; tubal ligation; intra-uterine device; barrier contraceptive with spermicide; or vasectomized partner) throughout the study.
- •Patients unable or unwilling to give written, informed consent.
- •Severe, active co-morbidity, defined as follows:
- •Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months.
- •Transmural myocardial infarction within the last 6 months.
- •Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration.
- •Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy within 30 days before registration.
- •Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; note, however, that laboratory tests for liver function and coagulation parameters are not required for entry into this protocol.
- •Acquired Immune Deficiency Syndrome (AIDS) based upon current CDC definition; note, however, that HIV testing is not required for entry into this protocol. Protocol-specific requirements may also exclude immuno-compromised patients.
- •History of treatment with potent immunosuppressive drugs for such conditions as post organ transplant, severe rheumatoid arthritis, etc. within the past 6 months.
- •Subjects must not be pregnant or nursing due to the potential for congenital abnormalities and the potential of this regimen to harm nursing infants
- •Evidence of metastatic disease
结局指标
主要结局
toxicities
时间窗: 90 days
Number of participants with acute related serious adverse events
次要结局
- quality of life(5 years)
- dosimetric improvement(2 weeks)
- adverse events(2 years)
- disease control(5 years)
研究者
研究点 (2)
Loading locations...
相似试验
进行中（未招募）
不适用
Hypofractionated Stereotactic Body Radiation Therapy for Patients With Prostate Cancer That Was Removed by SurgeryStage II Prostate AdenocarcinomaStage IIB Prostate CancerStage III Prostate AdenocarcinomaNCT02446366University of Southern California24
已完成
1 期
Stereotactic Radiation, Nelfinavir Mesylate & Neoadjuvant Chemotherapy in Locally Advanced Pancreatic CancerAdenocarcinoma of the PancreasStage III Pancreatic CancerNCT01068327University of Nebraska46
进行中（未招募）
1 期
Phase I Dose Escalation of Single Fraction Adjuvant Stereotactic Body Partial Breast Irradiation Early Stage Breast CAEarly Stage Breast CancerNCT02685332University of Texas Southwestern Medical Center30
招募中
1 期
Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal CancerMalignant Neoplasms of Respiratory and Intrathoracic OrgansSquamous Cell Carcinoma of the LarynxNCT03114462M.D. Anderson Cancer Center11
已完成
不适用
Stereotactic Body Radiation Therapy (SBRT) for Prostate CancerProstatic NeoplasmNCT01540994Sharp HealthCare12