Exercise for people living with obesity, diabetes and heart disease: clinical and functional outcomes and quality of life.

• Conditions: Obesity; Type II Diabetes (T2DM) complicated with Cardiovascular Disease; Cardiovascular - Other cardiovascular diseases; Metabolic and Endocrine - Diabetes; Diet and Nutrition - Obesity

• Registration Number: ACTRN12607000360415
• Lead Sponsor: Associate Professor Steve Selig

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-07-04
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

Volunteers T2DM with waist girth > 102 cm for males and > 88 cm for females and cardiovascular co-morbidity manifested by one or more of these;-Hypertension;Ischemic Heart Disease, but no current angina;Post Angioplasty / Stent or Post CABG;Chronic Heart Failure New York Association (NYHA I, II or III but not IV) in the absence of congestive heart failure at the time of study;Stable pharmacological therapy;All T2DM candidates HbA1c range should between 7 – 10 %.Volunteers must be sedentary with less than 30 minutes of strength training and/or moderate/vigorous aerobic exercise per week for at least 3 months prior to commencement in the study.

Exclusion Criteria

History of myocardial infarction, Cardiac arrest, symptomatic or sustained ventricular tachycardia in the previous 6 months;Unstable heart failure with NYHA Class IV patients;Positive Stress Test or current anginaCurrent musculoskeletal (e.g. arthritis) and/or neurological impairments that adversely affect exercise capacity;Baseline assessment suggesting unsatisfactory control of heart failure, Symptoms preventing the undertaking of exercise, Exercise-induced ventricular tachycardia (symptomatic or sustained) orBlood pressure drop of more 20 mmHg during baseline exercise test (VO2peak).All volunteers will be advised to continue taking individual medications.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Combined aerobic and resistance exercise training in people living with obesity-related diabetes and cardiovascular will:<br>1. increase (improve) VO2peak [Each measurement will be taken when the pre-study begins, at a 2 months interval and post completion (after 6 months)];Combined aerobic and resistance exercise training in people living with obesity-related diabetes and cardiovascular will:<br>2. decrease (improve) HbA1c.[Each measurement will be taken when the pre-study begins, at a 2 months interval and post completion (after 6 months)]

Secondary Outcome Measures

Name	Time	Method
Combined aerobic and resistance exercise training in people living with obesity-related diabetes and cardiovascular will improve:<br>1. musculoskeletal strength and endurance<br>2. functional capacity, improve quality of life (QoL)<br>3. blood pressure<br>4. lipid profile<br>5. flow-mediated dilation of the brachial artery.[All the experimental measures taken when the pre-study begins at baseline, at a 2 months interval and post completion (after 6 months).]