Comparative evaluation of anti-bacterial effect of silk suture coated with curcumin nano particles and uncoated silk suture in periodontal flap surgery: A Microbiological study.

This in vivo clinical study aims to assess and compare the antibacterial efficacy of silk sutures coated with curcumin nanoparticles and conventional uncoated silk sutures used during periodontal flap surgery. Curcumin, a natural compound with proven antibacterial and anti-inflammatory properties is hypothesized to reduce bacterial colonization when coated on sutures. A total of 10 patients with chronic generalized periodontitis, having more than or equal to 30 percent sites with pocket depth more than or equal to 5 mm after phase I therapy will be selected from the Outpatient Department of Periodontology Bharati Vidyapeeth Dental College & Hospital Pune.

Each patient will undergo periodontal flap surgery during which both types of sutures that is coated and uncoated will be alternately used in the same surgical site. After 7 days, sutures will be removed and transferred to phosphate-buffered saline for microbiological analysis. Using the roll plate method total bacterial colony-forming units will be counted to determine microbial load. The findings are expected to guide the use of antibacterial-coated sutures to minimize postoperative infection and improve healing in periodontal surgery.