Relevance of Vascular Function Markers: Study on the Effects of Quercetin and Epicatechin on Blood Pressure and Vascular Function in (Pre)Hypertensive Subjects

Completed

• Conditions: High blood pressure; vascular function; 10057166

• Registration Number: NL-OMON39481
• Lead Sponsor: TI Food and Nutrition

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

• Systolic Blood Pressure between 125 and 159 mmHg
• Age between 30 and 80 years
• BMI > 20 and <= 40

Exclusion Criteria

• Hisory of CVD
• Diabetes
• Usage of cholesterol-lowering medication
• Usage of non-steroidal anti-inflammatory drugs (acetylsalicylic acid, ibuprofen, naproxen) and not able or willing to stop taking them from at least 4 weeks prior to the study
• Smokers
• Weight loss or weight gain of 5 kg or more during the last 2 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome is the change in Flow-Mediated Dilation (FMD) as a marker<br /><br>of vascular function.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes include:<br /><br><br /><br>- Blood Pressure<br /><br>- Pulse-Wave Velocity<br /><br>- Pulse Wave Analysis<br /><br>- Vasomotion<br /><br>- Biomarkers of vascular and endothelial function<br /><br>- Biomarkers of inflammation<br /><br>- Glucose resistance (HOMA-IR) </p><br>