The role of filaggrin loss-of-function mutations in skin barrier and inflammatory response

• Conditions: Irritant contact dermatitis + Atopic dermatitis / Hand eczema + atopic eczema; 10014982

• Registration Number: NL-OMON36165
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Caucasian
Age between 18 - 55 years

Exclusion Criteria

Visible dermatitis on the forearms
Systemic inflammatory disease or skin diseases other than AD
Sunbathing or using a tanning bed during 2 months prior to the investigation
Use of antihistaminics or inflammation suppressing medicines (e.g. corticosteroids, NSAIDs) or antibiotics three months prior to, or during the investigation.

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Changes in transepidermal water loss (TEWL), pH and erythema<br /><br>2. Levels of filaggrin degradation products and cytokines in the stratum<br /><br>corneum harvested by using adhesive tape<br /><br>3. Skin morphology as assessed by using confocal laser scanning microscopy<br /><br>(Vivascope, MAVIG, Germany)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>