Metabolic Effects of One-weak Heavy Drinking

Not Applicable

Completed

• Conditions: Metabolic Disturbance; Alcohol; Harmful Use; Glucose Intolerance
• Interventions: Behavioral: Festival participation

• Registration Number: NCT04229550
• Lead Sponsor: University Hospital, Gentofte, Copenhagen

Brief Summary

Examination of the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016.

Detailed Description

Metabolic effects of intermittent unhealthy lifestyle in otherwise young healthy adults are poorly studied. The investigators evaluated the effect of one week's unhealthy lifestyle on glucose metabolism and liver parameters in a group of young, healthy males participating in Roskilde Festival 2016.

Festival participants were studied before and after participation (one week) in Roskilde Festival 2016 and matched with controls who lead a normal life for an equivalent period of time. An oral glucose tolerance test (OGTT), abdominal ultrasound and strain elastography for liver stiffness were performed together with a bioimpedance scan and cognitive tests.

Study Timeline

• Study Start: 2016-06-01
• Primary Completion: 2016-07-04
• Study Completion: 2016-07-04
• Status Verified: 2020-01
• Study First Submitted: 2020-01-08
• Study First Submitted QC: 2020-01-12
• Last Update Submitted: 2020-01-12
• Study First Posted: 2020-01-18
• Last Update Posted: 2020-01-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 28

Inclusion Criteria

• BMI of 18,5-25 kg/m2
• Normal liver function (assessed by ASAT, ALAT, GGT, alkaline phosphatase, albumin and bilirubin, coagulation factors II, VII and X, INR and platelets)

Exclusion Criteria

• Planning alcohol withdrawal or dieting/a special low-fat diet during Roskilde Festival
• Diabetes or pre-diabetes
• First degree relatives with diabetes
• Kidney disease (eGFT<60 ml/min and/or albuminuria)
• Chronic diseases (in addition to those already mentioned) that could affect participation in festival activities (concerts and parties)
• Any condition in which the investigator believed would make it impossible to participate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Festival subjects	Festival participation	1 week's participation in Roskilde Festival 2016

Primary Outcome Measures

Name	Time	Method
Impairment of glucose tolerance	First day after intervention week	Evaluated by OGTT

Secondary Outcome Measures

Name	Time	Method
Hepatic steatosis	First day after intervention week	Evaluated by abdominal ultrasound scan