Effect of simvastatin 20mg in bone formation after Removal of lower third molar teeth
- Conditions
- Hydroxymethylglutaryl-CoA Reductase InhibitorsD02.455.426.559.847.638.400.900G11.427.213.140A14.549.167.860.525.500Simvastatin, bone regeneration, Molar, Third.D27.505.519.186.071.202.370
- Registration Number
- RBR-523n7r
- Lead Sponsor
- Faculdade de Odontologia de Pernambuco, Universidade de Pernambuco - UPE
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Data analysis completed
- Sex
- Not specified
- Target Recruitment
- Not specified
The inclusion criteria were as follows: adult patients aged between 18-40 years old, of both genres, of any ethnicity, healthy, without allergy to the drugs used in the research or its components and who are not using any other medication. All patients must have both lower third molars, included, with the same inclusion pattern according to the Pell & Gregory classification, healthy, with indication of extraction and without signs of pericoronitis or inflammation.
The exclusion criteria were: patients with an inability to open their mouth for surgery; exceed 40 minutes in any surgery; fracture or postoperative infection; recent history of chemotherapy and / or radiation to the head and neck; giving up participating in the research at some point; make use of medications that have a known interaction with any drugs used in the study; smokers, pregnant or lactating women; did not perform the tests requested in the postoperative period.
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The bone volume, verified by the analysis of 2 cone-beam scans for each patient, based on the observation of a variation of at least 4.23 mm³ in favor of the intervention group.;The Percentage of bone volume (BV / TV), verified by analysis of 2 cone-beam tomographies for each patient, based on the observation of a variation of at least 0.07 mm³ in favor of the intervention group.
- Secondary Outcome Measures
Name Time Method The pain was verified using the visual analog scale (VAS), based on the observation of a significant difference between the groups at the following times: 2, 4, 6, 8, 24, 48 and 72h (p <0.05).;The swelling, verified through the evaluation through the measurement of three facial measures, from the verification of a variation of at least 2.23mm in favor of the test group after 72h.;Alveolar healing, verified through the Landry index, based on the finding of a worse local tissue repair profile in the test group (p <0.01) compared to the control group.